(2S)-2-氨基-3,3,3-三氟-1-丙醇 | 561323-79-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: (2S)-2-氨基-3,3,3-三氟-1-丙醇
• 英文名称: (S)-2-amino-3,3,3-trifluoropropan-1-ol
• 英文别名: (2S)-2-amino-3,3,3-trifluoropropan-1-ol
• CAS: 561323-79-3
• 化学式: C₃H₆F₃NO
• mdl: MFCD19213099
• 分子量: 129.082
• InChiKey: SGTSVIYDHWMNGL-REOHCLBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,6-二氟-4-碘吡啶 、 (2S)-2-氨基-3,3,3-三氟-1-丙醇 在 potassium carbonate 作用下， 以 二甲基亚砜 为溶剂， 反应 2.0h， 以5%的产率得到(2S)-3,3,3-trifluoro-2-[(6-fluoro-4-iodopyridin-2-yl)amino]propan-1-ol
  参考文献：
  名称：

  [EN] INHIBITORS OF RAF KINASES
  [FR] INHIBITEURS DE KINASES RAF

  摘要：

  本文提供了抑制受体酪氨酸激酶效应子RAF的药物，包括所述化合物的药物组合物，以及使用这些化合物治疗疾病的方法。

  公开号：

  WO2021081375A1

文献信息

• Discovery of APD371: Identification of a Highly Potent and Selective CB₂ Agonist for the Treatment of Chronic Pain
  作者：Sangdon Han、Lars Thoresen、Jae-Kyu Jung、Xiuwen Zhu、Jayant Thatte、Michelle Solomon、Ibragim Gaidarov、David J. Unett、Woo Hyun Yoon、Jeremy Barden、Abu Sadeque、Amin Usmani、Chuan Chen、Graeme Semple、Andrew J. Grottick、Hussein Al-Shamma、Ronald Christopher、Robert M. Jones

  DOI：10.1021/acsmedchemlett.7b00396

  日期：2017.12.14

  The discovery of a novel, selective and fully efficacious CB2 agonist with satisfactory pharmacokinetic and pharmaceutical properties is described. Compound 6 was efficacious in a rat model of osteoarthritis pain following oral administration and, in contrast to morphine, maintained its analgesic effect throughout a 5-day subchronic treatment paradigm. These data were consistent with our hypothesis that full agonist efficacy is required for efficient internalization and recycling of the CB2 receptor to avoid tachyphylaxis. Based on its overall favorable preclinical profile, 6 (APD371) was selected for further development for the treatment of pain.
• Identification of a broad-Spectrum azasordarin with improved pharmacokinetic properties
  作者：Michael H. Serrano-Wu、Denis R.St. Laurent、Tina M. Carroll、Marco Dodier、Qi Gao、Patrice Gill、Claude Quesnelle、Anne Marinier、Charles E. Mazzucco、Alicia Regueiro-Ren、Terry M. Stickle、Dedong Wu、Hyekyung Yang、Zheng Yang、Ming Zheng、Mary E. Zoeckler、Dolatrai M. Vyas、Balu N. Balasubramanian

  DOI：10.1016/s0960-894x(03)00161-6

  日期：2003.4

  The synthesis and antifungal activity of 5- and 5'-6'-substituted azasordarin derivatives are described. Modification of the 5'-position led to the discovery of the spirocyclopentyl analogue 7g, which is the first azasordarin to register single-digit MIC values versus Aspergillus spp. Further investigation identified the 5'-i-Pr derivative 7b, which displays superior pharmacokinetic properties compared to other azasordarins. (C) 2003 Elsevier Science Ltd. All rights reserved.