(2S,3S)-(+)-2,3-双(二苯基膦基)双环[2.2.1]庚-5-烯 | 71042-54-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (2S,3S)-(+)-2,3-双(二苯基膦基)双环[2.2.1]庚-5-烯
• 中文别名: (2R,3R)-(-)-2,3-双(二苯基膦)二环[2.2.1]庚基-5-烯
• 英文名称: (-)-Norphos
• 英文别名: (5R,6R)-5,6-Bis(diphenylphosphino)bicyclo[2.2.1]hept-2-ene；[(2R,3R)-3-diphenylphosphanyl-2-bicyclo[2.2.1]hept-5-enyl]-diphenylphosphane
• CAS: 71042-54-1；71042-55-2；76740-45-9；121902-85-0
• 化学式: C₃₁H₂₈P₂
• 分子量: 462.511
• InChiKey: CDJHPMXMJUCLPA-YRNSEASESA-N

物化性质

• 熔点：
  120 °C
• 比旋光度：
  +47° (c 1, CHCl3)
• 沸点：
  577.0±50.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• TSCA：
  No
• 危险品标志：
  Xi
• 危险类别码：
  R36/37/38
• 海关编码：
  2902909090
• 安全说明：
  S24/25
• 危险性防范说明：
  P264,P280,P302+P352+P332+P313+P362+P364,P305+P351+P338+P337+P313
• 危险性描述：
  H315,H319

反应信息

• 作为产物：
  描述：

  Bicyclo[2.2.1]hept-5-ene-2,3-diylbis(diphenylphosphane) dioxide 、 三氯硅烷 以75%的产率得到
  参考文献：
  名称：

  BRUNNER H.; PIERONCZYK W.; SCHOENHAMMER B.; STRENG K.; BERNAL I.; KORP J., CHEM. BER., 1981, 114, NO 3, 1137-1149

  摘要：

  DOI：

文献信息

• Process for the preparation of tricyclic amino alcohol derivatives
  申请人：ASAHI KASEI KABUSHIKI KAISHA

  公开号：US20030225289A1

  公开（公告）日：2003-12-04

  A process for the preparation of tricyclic amino alcohol derivatives including 2-[N-[2-(9H-carbazol-2-yloxy)ethyl]]amino-1-[(3-methylsulfonylamino)phenyl]ethanol useful in the treatment of diabetes, obesity, hyperlipidemia and so on; and intermediates as represented by formula (5) or (6) or the like useful in the preparation, wherein R11 is hydrogen or the like; and *1 represents an asymmetric carbon atom. 2-Halo-1-(3-nitrophenyl)ethanone derivatives and 1-(3-nitrophenyl)oxirane derivatives, which are intermediates for the preparation of tricyclic amino alcohol derivatives, are easy of purification, and particularly optically active 1-(3-nitrophenyl)oxirane derivatives are effective in enhancing the optical purities of the final products.

  一种用于制备包括2-[N-[2-(9H-咔唑-2-氧基)乙基]]氨基-1-[3-(甲磺酰氨基)苯基]乙醇在内的三环氨基醇衍生物的方法，该方法在治疗糖尿病、肥胖、高脂血症等方面有用；以及用公式(5)或(6)等表示的中间体，在制备中有用，其中R11是氢等；*1代表一个不对称碳原子。2-卤代-1-(3-硝基苯基)乙酮衍生物和1-(3-硝基苯基)环氧衍生物是用于制备三环氨基醇衍生物的中间体，易于纯化，特别是光学活性的1-(3-硝基苯基)环氧衍生物在提高最终产品的光学纯度方面是有效的。
• METHOD FOR THE PREPARATION OF TRICYCLIC AMINO ALCOHOL DERIVATIVES THROUGH AZIDES
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP1174426A1

  公开（公告）日：2002-01-23

  The present invention is directed to processes for the preparation of a tricyclic amino-alcohol derivative useful for treating and preventing diabetes, obesity, hyperlipidemia and the like, which compound is represented by the formula (1): wherein R1 represents a lower alkyl group or a benzyl group; *1 represents an asymmetric carbon atom; R2 represents a hydrogen atom, a halogen atom or a hydroxyl group; and A represents one of the following groups: wherein X represents NH, O or S; R5 represents a hydrogen atom, a hydroxyl group, an amino group or an acetylamino group; and *2 represents an asymmetric carbon atom when R5 is not a hydrogen atom. The processes of the present invention proceed via azide derivatives and are convenient, practical preparing processes with low cost which comprise a small number of steps with good industrial work efficiency.

  本发明涉及一种用于治疗和预防糖尿病、肥胖、高脂血症等疾病的三环氨基醇衍生物的制备方法，该化合物由以下式子表示（1）： 其中R1代表较低的烷基或苄基；*1代表一个不对称碳原子；R2代表氢原子、卤素原子或羟基；A代表以下其中一种基团： 其中X代表NH、O或S；R5代表氢原子、羟基、氨基或乙酰氨基；*2代表一个不对称碳原子，当R5不是氢原子时。本发明的方法通过叠氮衍生物进行，是方便、实用、成本低廉的制备方法，包括少量步骤且具有良好的工业工作效率。
• METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND
  申请人：DOT Therapeutics-1, Inc.

  公开号：US20200317659A1

  公开（公告）日：2020-10-08

  The aim of the present invention is to provide a method capable of producing an optically active pyrimidinamide derivative on an industrial scale. Compound (I) or a salt thereof is subjected to an asymmetric reduction reaction, the obtained compound (II) or a salt thereof is subjected to a deprotection reaction, and the obtained compound (III) or a salt thereof is reacted with compound (VI) or a salt thereof to obtain compound (V) or a salt thereof. wherein each symbol is as defined in the specification.

  本发明的目的是提供一种能够在工业规模上生产光学活性嘧啶酰胺衍生物的方法。化合物（I）或其盐经过不对称还原反应，得到的化合物（II）或其盐经过去保护反应，得到的化合物（III）或其盐与化合物（VI）或其盐反应，得到化合物（V）或其盐，其中每个符号如规范中定义的那样。
• Process for Production of Optically Active Quinuclidinols
  申请人：Noyori Ryoji

  公开号：US20090216019A1

  公开（公告）日：2009-08-27

  A novel ruthenium complex which is a highly efficient catalyst useful for the production of optically active 3-quinuclidinols, and a process for production of optically active 3-quinuclidinols using the ruthenium complex as a catalyst, where the optically active 3-quinuclidinols are useful as an optically active, physiologically active compound utilized in medicines and agrichemicals or as a synthetic intermediate such as a liquid crystal material.

  一种新颖的钌配合物，是一种高效催化剂，可用于生产光学活性的3-喹诺啉醇，并且提供一种以该钌配合物为催化剂生产光学活性3-喹诺啉醇的方法，其中光学活性的3-喹诺啉醇可用作光学活性、生理活性的化合物，用于药物和农药，或者作为合成中间体，如液晶材料。
• PREPARATION OF CHIRAL AMIDES AND AMINES
  申请人：Zhao Hang

  公开号：US20090149549A1

  公开（公告）日：2009-06-11

  This invention provides a convenient method for converting oximes into enamides. The process does not require the use of metallic reagents. Accordingly, it produces the desired compounds without the concomitant production of a large volume of metallic waste. The enamides are useful precursors to amides and amines. The invention provides a process to convert a prochiral enamide into the corresponding chiral amide. In an exemplary process, a chiral amino center is introduced during hydrogenation through the use of a chiral hydrogenation catalyst. In selected embodiments, the invention provides methods of preparing amides and amines that include the 1,2,3,4-tetrahydro-N-alkyl-1-naphthalenamine or 1,2,3,4-tetrahydro-1-naphthalenamine substructure.

  这项发明提供了一种方便的方法，将肟转化为烯酰胺。该过程不需要使用金属试剂。因此，它能够产生所需化合物，而不会伴随产生大量金属废物。烯酰胺是酰胺和胺的有用前体。该发明提供了将一个原生手性烯酰胺转化为相应手性酰胺的过程。在一个示范过程中，通过使用手性氢化催化剂，在氢化过程中引入了手性氨基中心。在选定的实施例中，该发明提供了制备酰胺和胺的方法，其中包括1,2,3,4-四氢-N-烷基-1-萘胺或1,2,3,4-四氢-1-萘胺亚结构。