(3-氨基苯基)-(4-甲氧基苯基)甲酮 | 62261-35-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (3-氨基苯基)-(4-甲氧基苯基)甲酮
• 英文名称: (3-aminophenyl)-(4-methoxyphenyl)methanone
• 英文别名: (3-aminophenyl)(4-methoxyphenyl)methanone；4-CH3OC6H4C(O)C6H4NH2；3-amino-4'-methoxy-benzophenone；3-Amino-4'-methoxy-benzophenon
• CAS: 62261-35-2
• 化学式: C₁₄H₁₃NO₂
• mdl: MFCD09035574
• 分子量: 227.263
• InChiKey: GHHYIYWROJLOLU-UHFFFAOYSA-N

物化性质

• 熔点：
  114-116 °C(Solv: methanol (67-56-1))
• 沸点：
  426.6±30.0 °C(Predicted)
• 密度：
  1.172±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (3-氨基苯基)-(4-甲氧基苯基)甲酮 在 吡啶 、 盐酸羟胺 作用下， 以 乙醇 为溶剂， 反应 11.0h， 生成 Propane-2-sulfonic acid {3-[[(Z)-hydroxyimino]-(4-methoxy-phenyl)-methyl]-phenyl}-amide
  参考文献：
  名称：

  Synthesis and antiviral activity of sulfonamidobenzophenone oximes and sulfonamidobenzamides

  摘要：

  To find antiviral agents, various sulfonamidobenzophenone oximes (II) were synthesized from the appropriate m-sulfonamidobenzophenones by hydroxylamine reaction. The reaction products were generally obtained as syn/anti mixtures which were separable by fractional crystallization. The anti isomer had more potent antipoliovirus activity than the syn isomer. Various sulfonamidobenzamides (III) which were structurally related to II were synthesized by the reactions of amino-substituted benzamides with sulfuryl chloride or amines with (aminosulfonyl)benzoyl chloride. Antiviral activity was examined by the plaque-inhibition test. Compounds 5, 36, and 69 exhibited strong antipicornavirus activity. The structure-activity relationships are discussed.

  DOI：

  10.1021/jm00153a018
• 作为产物：
  描述：

  (4-甲氧基苯基)-(3-硝基苯基)甲酮 在 钯 作用下， 生成 (3-氨基苯基)-(4-甲氧基苯基)甲酮
  参考文献：
  名称：

  Oelschlaeger, Arzneimittel-Forschung/Drug Research, 1958, vol. 8, p. 532,536

  摘要：

  DOI：

文献信息

• Direct preparation of new organozinc reagents, aminophenylzinc iodides, and their applications
  作者：Hye-Soo Jung、Seung-Hoi Kim

  DOI：10.1016/j.tetlet.2015.01.053

  日期：2015.2

  New organozinc reagents, 4-aminophenyl zinc iodide (A) and 3-aminophenyl zinc iodide (B), have been generated easily and effectively by the direct insertion of active zinc to iodoanilines which possess acidic protons. The subsequent coupling reactions of the organozincs with various acid chlorides turned out to be an efficient tool for the preparation of aminophenyl ketones.

  通过将活性锌直接插入具有酸性质子的碘代苯胺中，可以轻松而有效地产生新的有机锌试剂，即4-氨基苯基碘化锌（A）和3-氨基苯基碘化锌（B）。后来有机锌与各种酰氯的偶合反应被证明是制备氨基苯基酮的有效工具。
• METHOD OF MANUFACTURING BIPYRIDINIUM COMPOUND AND SYNTHETIC INTERMEDIATE OF THE SAME, METHOD OF MANUFACTURING DYE COMPOUND, AND NOVEL BIPYRIDINIUM COMPOUND AND NOVEL DYE COMPOUND COMPRISING THE SAME
  申请人：Nii Kazumi

  公开号：US20090082570A1

  公开（公告）日：2009-03-26

  Provided is a method of manufacturing a bipyridinium compound denoted by general formula (A). In general formula (A), Ar 1 and Ar 2 each independently denote an optionally substituted (hetero)aryl group, R 3 and R 4 each independently denote a substituent that may form a ring with a pyridine ring to which the substituent substitutes, m3 and m4 each independently denote an integer ranging from 0 to 4, X denotes a halogen atom or RSO 3 , and R denotes an optionally substituted aryl group or alkyl group. The method can manufacture a 4,4′-bipyridinium compound under mild reaction conditions in an integrated manner without separation of intermediates.

  提供了一种制造双吡啶化合物的方法，其通用式为(A)。在通用式(A)中，Ar1和Ar2分别独立表示可选择取代的(杂)芳基团，R3和R4分别独立表示可与取代基形成环的基团，m3和m4分别独立表示范围从0到4的整数，X表示卤原子或RSO3，R表示可选择取代的芳基团或烷基团。该方法可以在温和的反应条件下以一体化方式制造4,4'-双吡啶化合物，无需中间体的分离。
• Efficient One‐Pot Friedel–Crafts Acylation of Benzene and its Derivatives with Unprotected Aminocarboxylic Acids in Polyphosphoric Acid
  作者：Iliyan Ivanov、Stoyanka Nikolova、Stela Statkova‐Abeghe

  DOI：10.1080/00397910500522124

  日期：2006.6.1

  Abstract A number of aminobenzophenones have been synthesized by acylation of benzene and its derivatives with different 2‐,3‐,4‐aminobenzoic and 4‐aminophenylacetic acids in polyphosphoric acid via Friedel–Crafts reaction as compounds with expected antitumor activity.

  摘要 苯及其衍生物与多磷酸中不同的 2-,3-,4-氨基苯甲酸和 4-氨基苯乙酸通过 Friedel-Crafts 反应酰化合成了许多氨基二苯甲酮，作为具有预期抗肿瘤活性的化合物。
• Heterobicyclic derivatives
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：US20020107251A1

  公开（公告）日：2002-08-08

  Heterobicyclic derivatives of the formula: 1 wherein R 1 is aryl which may have suitable substituent(s), ar(lower)alkyl which may have suitable substituent(s), halo(lower)alkyl, protected carboxy(lower)alkyl, acyl(lower)alkyl, heterocyclic group or heterocyclic(lower)alkyl which may have suitable substituent(s), R 2 is aryl which may have suitable substituent(s) or heterocyclic group, and R 3 is hydrogen, lower alkoxy or arylthio, and a pharmaceutically acceptable salt thereof which are useful as a medicament.

  公式为1的杂环双环衍生物，其中：R1是苯基，可以具有适当的取代基；芳基（较低）烷基，可以具有适当的取代基；卤代（较低）烷基；保护的羧基（较低）烷基；酰基（较低）烷基；杂环基或者可以具有适当的取代基的杂环（较低）烷基；R2是苯基，可以具有适当的取代基或者杂环基；R3是氢、较低烷氧基或者芳基硫醚。它们的药物可接受盐是有用的。
• Verfahren zur Herstellung von gegebenenfalls zelligen Polyurethan-Polyharnstoff-Formkörpern
  申请人：BASF Aktiengesellschaft

  公开号：EP0109624A2

  公开（公告）日：1984-05-30

  Die Erfindung betrifft ein Einstufen-Verfahren zur Herstellung von zelligen oder vorzugsweise kompakten Polyurethan-Polyharnstoff-Formkörpern, vorzugsweise mit Hilfe der Reaktionsspritzgußtechnik, durch Umsetzung von organischen Polyisocyanaten, Polyolen und gegebenenfalls substituierten Diaminoazobenzolen, vorzugsweise 4,4'- und/oder 2,4'-Diaminoazobenzolen, Diaminoazopyridinen und/oder deren Oxide in Gegenwart von Katalysatoren sowie gegebenenfalls Treibmitteln, Hilfs- und Zusatzstoffen.

  本发明涉及一种生产蜂窝状聚氨酯-聚脲模塑件的一步法工艺，最好采用反应注 塑技术，在催化剂和可选发泡剂、助剂和添加剂的存在下，使有机多异氰酸酯、多元 醇和可选取代的二氨基偶氮苯，最好是 4,4'-和/或 2,4'-二氨基偶氮苯、二氨基偶氮吡啶和/ 或其氧化物发生反应。