(3-溴-1-(2-溴乙基)-丙基)苯 | 27070-24-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (3-溴-1-(2-溴乙基)-丙基)苯
• 英文名称: (3-bromo-1-(2-bromoethyl)-propyl)benzene
• 英文别名: (1,5-dibromopentan-3-yl)benzene；1,5-dibromo-3-phenylpentane；1,5-dibromo-3-phenyl-pentane；1,5-Dibrom-3-phenyl-pentan；1,5-Dibrom-3-phenylpentan；1,5-dibromopentan-3-ylbenzene
• CAS: 27070-24-2
• 化学式: C₁₁H₁₄Br₂
• 分子量: 306.04
• InChiKey: KZJVHRMHEJITGV-UHFFFAOYSA-N

物化性质

• 沸点：
  137 °C(Press: 3 Torr)
• 密度：
  1.5521 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  (3-溴-1-(2-溴乙基)-丙基)苯 在 氢氧化钾 、 乙醇 作用下， 生成 4-苯基-庚二酸
  参考文献：
  名称：

  AN ATTEMPTED SYNTHESIS OF A TRICYCLIC SYSTEM PRESENT IN MORPHINE

  摘要：

  DOI：

  10.1021/ja01354a044
• 作为产物：
  描述：

  1-Hydroxy-5-methoxy-3-phenylpentane 生成 (3-溴-1-(2-溴乙基)-丙基)苯
  参考文献：
  名称：

  Synthesis of 4-substituted thiacyclohexanes

  摘要：

  DOI：

  10.1007/bf00963317

文献信息

• [EN] CHEMOKINE RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DE RÉCEPTEURS DE CHIMIOKINES
  申请人：ABBOTT LAB

  公开号：WO2013149376A1

  公开（公告）日：2013-10-10

  Disclosed herein are chemokine receptor antagonists of formula (I) wherein R1, R2, and R3 are as defined in the specification. Compositions comprising such compounds; and methods for treating conditions and disorders using such compounds and compositions are also described.

  本文披露了化学受体拮抗剂的化学式(I)，其中R1、R2和R3如规范中所定义。还描述了包含这种化合物的组合物；以及使用这种化合物和组合物治疗疾病和疾病的方法。
• Fused imidazopyridine derivatives as antihyperlipidemic agents
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US06235731B1

  公开（公告）日：2001-05-22

  A novel compound of the formula: wherein ring Q is an optionally substituted pyridine ring; One of R0, R1 and R2 is —Y0—Z0, and the other tow groups are a hydrogen, a halogen, an optionally substituted hydroxy group, a hydrocarbon group that may be an optionally substituted hydrocarbon group or an acyl group; Y0 is a bond or an optionally substituted bivalent hydrocarbon group; Z0 is a basic group which may be bonded via oxygen, nitrogen, —CO—, —CS—, —SO2N(R3)— (where R3 is hydrogen or an optionally substituted hydrocarbon group), or S(O)n (wherein n is to 0, 1 or 2); ......... is a single bond or a double bond, or a salt thereof, which has an excellent LDL receptor up-regulating, blood-lipids lowering, blood-sugar lowering and diabetic complication-ameliorating activity.

  其中环Q是一个可选择取代的吡啶环； R0、R1和R2中的一个是—Y0—Z0，另外两个基团是氢、卤素、可选择取代的羟基、可能是可选择取代的碳氢基团或酰基； Y0是一个键或一个可选择取代的二价碳氢基团； Z0是一种碱性基团，可以通过氧、氮、—CO—、—CS—、—SO2N(R3)—（其中R3是氢或可选择取代的碳氢基团）或S(O)n（其中n为0、1或2）与之键合； .........是一种单键或双键，或其盐，具有出色的LDL受体上调、降低血脂、降低血糖和改善糖尿病并发症的活性。
• Stereochemical Outcomes in Reductive Cyclizations To Form Spirocyclic Heterocycles
  作者：Matthew A. Perry、Richard R. Hill、Justin J. Leong、Scott D. Rychnovsky

  DOI：10.1021/acs.orglett.5b01422

  日期：2015.7.2

  Reductive lithiation and cyclization of N-Boc α-amino nitriles are often highly stereoselective. The alkyllithium intermediates are formed with varying levels of selectivity, but the alkyllithium geometry does not play a major role in the overall stereoselectivity. The final configuration is determined in the cyclization reaction, where both retention and inversion pathways are observed. Where strong

  N -Bocα-氨基腈的还原锂化和环化通常具有很高的立体选择性。形成的烷基锂中间体具有不同的选择性水平，但烷基锂的几何形状在总体立体选择性中不发挥主要作用。最终构型是在环化反应中确定的，在该反应中观察到了保留和转化途径。在产物中存在强烈的热力学偏好的地方，动力学控制的烷基锂环化有利于更稳定的产物。
• Stereochemistry of base-induced cleavage of methoxide ion on cis- and trans-1,4-diphenylphosphorinanium salts. A different behavior with a phenyl substituent
  作者：Susana López-Cortina、Araceli Medina-Arreguin、Eugenio Hernández-Fernández、Sylvain Bernès、Jorge Guerrero-Alvarez、Mario Ordoñez、Mario Fernández-Zertuche

  DOI：10.1016/j.tet.2010.05.095

  日期：2010.8

  ium tetrafluoroborate salts 11a and 11b, molecules designed to evaluate the effect of a phenyl substituent at C-4 on the stereochemical course of base-induced nucleophilic displacement of the methoxy group at phosphorus, was accomplished. The presence of a phenyl substituent at C-4 changes the stereochemical course of these reactions, from complete inversion with alkyl groups to products where retention

  纯粹的顺式和反式-1,4-二苯基-1-甲氧基-磷鎓四氟硼酸盐11a和11b的合成和表征，旨在评估C-4处的苯基取代基对碱基诱导的立体化学过程的影响完成了磷上甲氧基的亲核取代。C-4处苯基取代基的存在改变了这些反应的立体化学过程，从烷基的完全转化到以磷保持构型为主的产物。我们提出了一种涉及Berry假旋转的机制，并提供了证据证明氢氧根离子通过富含17的NaOH的实验攻击磷原子。哦
• Synthesis of Five-Membered Cyclic Ketones Using Potassium Tetracarbonylferrate(2—)
  作者：Masakazu Yamashita、Masaya Uchida、Haruyoshi Tashika、Rikisaku Suemitsu

  DOI：10.1246/bcsj.62.2728

  日期：1989.8

  Various five-membered cyclic ketones were prepared from 1,4-dihaloalkanes and potassium tetracarbonylferrate(2—) in moderate to high yields. However, the yields of six- or seven-membered cyclic ketones from the corresponding dihalides were rather low.

  各种五元环酮由 1,4-二卤代烷烃和四羰基铁酸钾 (2-) 以中等至高产率制备。然而，来自相应二卤化物的六元或七元环酮的产率相当低。