3-nitro-N'-{[5-(2-pyridinylsulfanyl)-2-furyl]methylene}benzohydrazide

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 3-nitro-N'-{[5-(2-pyridinylsulfanyl)-2-furyl]methylene}benzohydrazide
• 英文别名: 3-nitro-N-[(E)-(5-pyridin-2-ylsulfanylfuran-2-yl)methylideneamino]benzamide
• 化学式: C17H12N4O4S
• 分子量: 368.4
• InChiKey: UHPDBDJDMSQTHE-YBFXNURJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  139
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• INHIBITORS OF EYA2
  申请人：Zhao Rui

  公开号：US20140155420A1

  公开（公告）日：2014-06-05

  The invention provides small molecule inhibitors of EYA2 phosphatase activity and EYA2 binding to Six1. These inhibitors are proposed for use in methods of treating cancer in a subject, such as those involving Six1 and/or EYA2 disregulation. In some embodiments, the invention further provides for the administration of a second cancer therapy to the subject.
• [EN] INHIBITORS OF EYA2<br/>[FR] INHIBITEURS D'EYA2
  申请人：UNIV COLORADO REGENTS

  公开号：WO2012096977A1

  公开（公告）日：2012-07-19

  The invention provides small molecule inhibitors of EYA2 phosphatase activity and EYA2 binding to Six1. These inhibitors are proposed for use in methods of treating cancer in a subject, such as those involving Six1 and/or EYA2 disregulation. In some embodiments, the invention further provides for the administration of a second cancer therapy to the subject.