(4R)-4-(2-hydroxyethyl)pyrrolidin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (4R)-4-(2-hydroxyethyl)pyrrolidin-2-one
• 化学式: C₆H₁₁NO₂
• 分子量: 129.16
• InChiKey: USLIRRDZCYCNQT-RXMQYKEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• SYK INHIBITORS
  申请人：Gilead Sciences, Inc.

  公开号：EP3027601A1

  公开（公告）日：2016-06-08
• [EN] SYK INHIBITORS<br/>[FR] INHIBITEURS SYK
  申请人：GILEAD SCIENCES INC

  公开号：WO2015017610A1

  公开（公告）日：2015-02-05

  The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula (I): wherein X1, X2, X3, R2, R3, R4, R5, and Y are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.