(4-(氨基甲基)苯基)膦酸 | 98334-25-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (4-(氨基甲基)苯基)膦酸
• 英文名称: (4-aminomethyl-phenyl)-phosphonic acid
• 英文别名: (4-Aminomethyl-phenyl)-phosphonsaeure；(4-(Aminomethyl)phenyl)phosphonic acid；[4-(aminomethyl)phenyl]phosphonic acid
• CAS: 98334-25-9
• 化学式: C₇H₁₀NO₃P
• 分子量: 187.135
• InChiKey: OAMSKJWYWCTURE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  83.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (4-氨基苯基)磷酸 在 lithium aluminium tetrahydride 作用下， 生成 (4-(氨基甲基)苯基)膦酸
  参考文献：
  名称：

  p-Cyanophenylphosphonic Acid and Related Compounds¹

  摘要：

  DOI：

  10.1021/ja01521a027

文献信息

• [EN] QUINAZOLINE DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS<br/>[FR] DÉRIVÉS DE QUINAZOLINE UTILISÉS EN TANT QU'INHIBITEURS D'ECTONUCLÉOTIDE PYROPHOSPHATASE/PHOSPHODIESTÉRASE 1
  申请人：RIBOSCIENCE LLC

  公开号：WO2020140001A1

  公开（公告）日：2020-07-02

  The present disclosure provides certain quinazoline compounds that inhibit ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) enzymatic activity and are therefore useful for the treatment of diseases and conditions modulated at least in part by ENPP1. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

  本公开提供了一些抑制细胞外核苷酸焦磷酸酶/磷酸二酯酶1（ENPP1）酶活性的喹唑啉化合物，因此对于治疗至少部分受ENPP1调节的疾病和病况是有用的。还提供了含有这些化合物的药物组合物以及制备这些化合物的方法。
• Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds
  申请人：Arimilli N. Murty

  公开号：US20070010489A1

  公开（公告）日：2007-01-11

  Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit 5 HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.

  本发明揭示了具有HIV蛋白酶抑制剂性质的膦酸酯取代化合物，其具有作为治疗剂和其他工业用途的用途。该组合物抑制5型HIV蛋白酶活性和/或在治疗艾滋病和其他抗病毒感染方面具有治疗作用，以及在检测HIV蛋白酶方面的检测中有用。
• Method and compositions for identifying anti-hiv therapeutic compounds
  申请人：Birkus Gabriel

  公开号：US20070190523A1

  公开（公告）日：2007-08-16

  The invention relates to methods and compositions for identifying compounds having therapeutic activity against human immunodeficiency virus (HIV).

  本发明涉及用于鉴定具有治疗人类免疫缺陷病毒（HIV）活性的化合物的方法和组合物。
• Marathe et al., Journal Of Scientific and Industrial Research, 1950, vol. 9 B, p. 268
  作者：Marathe et al.

  DOI：——

  日期：——
• QUINAZOLINE DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS
  申请人：Riboscience LLC

  公开号：US20220056052A1

  公开（公告）日：2022-02-24

  The present disclosure provides certain quinazoline compounds that inhibit ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) enzymatic activity and are therefore useful for the treatment of diseases and conditions modulated at least in part by ENPP1. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.