2-[(2E)-2-{[5-(2-chlorophenyl)furan-2-yl]methylidene}hydrazinyl]benzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(2E)-2-{[5-(2-chlorophenyl)furan-2-yl]methylidene}hydrazinyl]benzoic acid
• 英文别名: 2-[(2E)-2-[[5-(2-chlorophenyl)furan-2-yl]methylidene]hydrazinyl]benzoic acid
• 化学式: C₁₈H₁₃ClN₂O₃
• 分子量: 340.8
• InChiKey: NMDZDMNJLCAJMA-RGVLZGJSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• NOVEL METHODS FOR TREATING NEURODEGENERATIVE DISEASES
  申请人：Genzyme Corporation

  公开号：EP3071199A2

  公开（公告）日：2016-09-28
• AMINO-BENZOIC ACID DERIVATIVES FOR USE IN THE TREATMENT OF DIHYDROGENASE-RELATED DISORDERS
  申请人：Mclean Larry Raymond

  公开号：US20120208855A1

  公开（公告）日：2012-08-16

  Provided herein is method of modulating, and in particular decreasing dihydroorotate dehydrogenase (DHODH) activity, as well as a method of treating a DHODH related disease or disorder.
• [EN] AMINO-BENZOIC ACID DERIVATIVES FOR USE IN THE TREATMENT OF DIHYDROGENASE-RELATED DISORDERS<br/>[FR] DÉRIVÉS DE L'ACIDE AMINOBENZOÏQUE DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE TROUBLES ASSOCIÉS À LA DÉSHYDROGÉNASE
  申请人：SANOFI AVENTIS

  公开号：WO2011053468A1

  公开（公告）日：2011-05-05

  Provided herein is method of modulating, and in particular decreasing dihydroorotate dehydrogenase (DHODH) activity, as well as a method of treating a DHODH related disease or disorder.
• [EN] NOVEL METHODS FOR TREATING NEURODEGENERATIVE DISEASES<br/>[FR] NOUVELLES MÉTHODES POUR TRAITER DES MALADIES NEURODÉGÉNÉRATIVES
  申请人：GENZYME CORP

  公开号：WO2015077535A2

  公开（公告）日：2015-05-28

  The invention relates to dihydroorate dehydrogenase (DHODH) inhibitors useful for the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis.