(4-氨基苯基)三甲基碘化铵盐酸盐 | 62654-12-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (4-氨基苯基)三甲基碘化铵盐酸盐
• 英文名称: (4-aminophenyl)-trimethylammonium iodide hydrochloride
• 英文别名: (4-aminophenyl)-trimethylazanium;hydron;chloride;iodide
• CAS: 62654-12-0
• 化学式: C₉H₁₅N₂*ClH*I
• 分子量: 314.597
• InChiKey: YLPUMVFEVOSYNP-UHFFFAOYSA-M

物化性质

• 熔点：
  190 °C
• 稳定性/保质期：
  遵照规定使用和储存，则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  -1.11
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S24,S26,S39
• 危险类别码：
  R36,R43

反应信息

• 作为反应物：
  描述：

  (4-氨基苯基)三甲基碘化铵盐酸盐 、 (R)-(-)-布洛芬 在 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 26.5h， 生成 R(-)-2-[(4'-isobutyl)phenyl]-N-[4-NNN-trimethylaminophenyl]-propionamide iodide
  参考文献：
  名称：

  Quaternary ammonium salts of omega-aminoalkylamides of r-2-aryl-propionic acids and pharmaceutical compositions containing them

  摘要：

  通用公式(I)的(R)-对映体的季铵盐被描述：其中R、R1、R2、R3、X和Z如描述中所定义。还描述了它们的制备过程和药物制剂。本发明的季铵盐在抑制由补体C5a分数诱导的中性粒细胞和单核细胞趋化方面具有用途，并用于治疗牛皮癣、天疱疮和天疱疮、类风湿关节炎、包括溃疡性结肠炎、急性呼吸窘迫综合征、特发性纤维化、囊性纤维化、慢性阻塞性肺病和肾小球肾炎在内的肠道慢性炎症病变。本发明的化合物有利地用于预防和治疗缺血再灌注引起的损伤。

  公开号：

  US20040266870A1

文献信息

• QUATERNARY AMMONIUM SALTS OF OMEGA-AMINOALKYLAMIDES OF R-2-ARYL-PROPIONIC ACIDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Dompé S.P.A.

  公开号：EP1430020A1

  公开（公告）日：2004-06-23
• US7026510B2
  申请人：——

  公开号：US7026510B2

  公开（公告）日：2006-04-11
• [EN] QUATERNARY AMMONIUM SALTS OF OMEGA-AMINOALKYLAMIDES OF R-2-ARYL-PROPIONIC ACIDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] SELS QUATERNAIRES D'AMMONIUM D'OMEGA-AMINOALKYLAMIDES DE L'ACIDE R-2-ARYL-PROPIONIQUE, ET PREPARATIONS PHARMACEUTIQUES LES CONTENANT
  申请人：DOMPE SPA

  公开号：WO2003029187A1

  公开（公告）日：2003-04-10

  (R)-Enantiomers of quaternary ammonium salts of general formula (I) are described: (I) where R, R1, R2, R3, X and Z are as defined in the description. The process for their preparation and pharmaceutical preparations thereof are also described. The quaternary salts of the invention are useful in the inhibition of chemotaxis of neutrophils and monocytes induced by the fraction C5a of the complement and are used in the treatment of psoriasis, pemphigus and pemphigoid, rheumatoid arthritis, intestinal chronic inflammatory pathologies including ulcerative colitis, acute respiratory distress syndrome, idiopathic fibrosis, cystic fibrosis, chronic obstructive pulmonary disease and glomerulonephritis. The compounds of the invention are advantageously used in the prevention and the treatment of injury caused by ischemia and reperfusion.
• Quaternary ammonium salts of omega-aminoalkylamides of r-2-aryl-propionic acids and pharmaceutical compositions containing them
  申请人：——

  公开号：US20040266870A1

  公开（公告）日：2004-12-30

  (R)-Enantiomers of quaternary ammonium salts of general formula (I) are described: 1 where R, R 1 , R 2 , R 3 , X and Z are as defined in the description. The process for their preparation and pharmaceutical preparations thereof are also described. The quaternary salts of the invention are useful in the inhibition of chemotaxis of neutrophils and monocytes induced by the fraction C 5 a of the complement and are used in the treatment of psoriasis, pemphigus and pemphigoid, rheumatoid arthritis, intestinal chronic inflammatory pathologies including ulcerative colitis, acute respiratory distress syndrome, idiopathic fibrosis, cystic fibrosis, chronic obstructive pulmonary disease and glomerulonephritis. The compounds of the invention are advantageously used in the prevention and the treatment of injury caused by ischemia and reperfusion.

  通用公式(I)的(R)-对映体的季铵盐被描述：其中R、R1、R2、R3、X和Z如描述中所定义。还描述了它们的制备过程和药物制剂。本发明的季铵盐在抑制由补体C5a分数诱导的中性粒细胞和单核细胞趋化方面具有用途，并用于治疗牛皮癣、天疱疮和天疱疮、类风湿关节炎、包括溃疡性结肠炎、急性呼吸窘迫综合征、特发性纤维化、囊性纤维化、慢性阻塞性肺病和肾小球肾炎在内的肠道慢性炎症病变。本发明的化合物有利地用于预防和治疗缺血再灌注引起的损伤。