photocatalytic procedure that enables the acylation/arylation of unfunctionalized alkyl derivatives in flow. The method exploits the ability of the decatungstate anion to act as a hydrogen atom abstractor and produce nucleophilic carbon-centered radicals that are intercepted by a nickel catalyst to ultimately forge C(sp3)−C(sp2) bonds. Owing to the intensified conditions in flow, the reaction time can be reduced
The present invention relates to methods of preparing fused ring indeno compounds that involves reacting together a dienophile and a lactone compound, in the presence of a catalyst, and a carboxylic acid anhydride. With some embodiments, the fused ring indeno compound is represented by the following Formula (I-A), the dienophile is represented by the following Formula (II-A), and the lactone compound is represented by the following Formula (III-A):
The present invention relates to photochromic indeno-fused ring pyran compounds represented by the following Formula (I-A):
The present invention also relates to photochromic dichroic compounds, such as represented by Formula (I-A), in which (i) Z
2
is a group N—R
13
in which R
13
is a group L, and (ii) optionally at least one R
1
independently for each n is selected from a group L, in which the group L independently in each case is a lengthening group that provides the photochromic compound with dichroic properties, in accordance with some embodiments. The present invention also relates to photochromic articles, such as photochromic ophthalmic articles, that include one or more photochromic compounds according to the present invention, such as represented by Formula (I-A).
[EN] HETEROCYCLIC COMPOUNDS AND METHODS FOR THEIR USE<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES ET PROCÉDÉS POUR LEUR UTILISATION
申请人:SPINIFEX PHARM PTY LTD
公开号:WO2013102242A1
公开(公告)日:2013-07-11
The present invention relates to heterocyclic compounds useful for antagonising angiotensin II Type 2 (AT2) receptor. More particularly the invention relates to pyrrolidine and azetidine compounds, compositions containing them and their use in methods of treating or preventing disorders or diseases associated with AT2 receptor function including neuropathic pain, inflammatory pain, conditions associated with neuronal hypersensitivity, impaired nerve conduction velocity, cell proliferation disorders, disorders associated with an imbalance between bone resorption and bone formation and disorders associated with aberrant nerve regeneration.
Fused Ring Indeno Compounds For Preparation Of Photochromic Compounds
申请人:Transitions Optical, Inc.
公开号:US20150141663A1
公开(公告)日:2015-05-21
The present invention relates to intermediate compounds represented by the following Formula (I-A),
The intermediate compounds of the present invention, such as represented by Formula (I-A), can be used to prepare photochromic compounds, such as photochromic fused ring indenopyran compounds, including but not limited to photochromic fused ring indeno-naphtho-pyran compounds.