(7aS)-2-苯基-3-硫代六氢-1H-吡咯并[1,2-c]咪唑-1-酮 | 29635-99-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 中文名称: (7aS)-2-苯基-3-硫代六氢-1H-吡咯并[1,2-c]咪唑-1-酮
• 中文别名: PTH-L-脯氨酸
• 英文名称: hexahydro-2-phenyl-3-thioxopyrrolo[1,2-c]imidazol-1-one
• 英文别名: (S)-2-phenyl-3-thioxo-hexahydro-pyrrolo[1,2-c]imidazol-1-one；(S)-2-Phenyl-3-thioxo-hexahydro-pyrrolo[1,2-c]imidazol-1-on；PTH-L-proline；(7aS)-2-phenyl-3-sulfanylidene-5,6,7,7a-tetrahydropyrrolo[1,2-c]imidazol-1-one
• CAS: 29635-99-2
• 化学式: C₁₂H₁₂N₂OS
• mdl: MFCD00070098
• 分子量: 232.306
• InChiKey: YNJJBMAKBUZCKN-JTQLQIEISA-N

物化性质

• 稳定性/保质期：
  如果按照规格使用和储存，不会发生分解，也没有已知的危险反应。

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  55.6
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090
• 储存条件：
  密封，在-20°C下保存

反应信息

• 作为反应物：
  描述：

  (7aS)-2-苯基-3-硫代六氢-1H-吡咯并[1,2-c]咪唑-1-酮 、 甲胺 反应 2.0h， 以95%的产率得到(2S)-N-methyl-1-(phenylcarbamothioyl)pyrrolidine-2-carboxamide
  参考文献：
  名称：

  Pavlik, Manfred; Kluh, Ivan; Pavlikova, Frantiska, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 7, p. 1940 - 1954

  摘要：

  DOI：
• 作为产物：
  描述：

  N-Phenylthiocarbamyl-L-prolin 以86%的产率得到
  参考文献：
  名称：

  POUPAERT J. H.; LHOEST G., BULL. SOC. CHIM. BELG., 1979, 88, NO 5, 339-342

  摘要：

  DOI：

文献信息

• Method for treating nerve injury caused as a result of surgery
  申请人：——

  公开号：US20030203890A1

  公开（公告）日：2003-10-30

  The present invention relates generally to methods for treating or preventing nerve injury in a warm-blooded animal caused as a consequence of surgery by administering neurotrophic compounds described below. The invention relates more specifically to methods for treating or preventing nerve injury caused as a consequence of prostate surgery as well as erectile dysfunction.

  本发明一般涉及通过给予下文描述的神经营养化合物来治疗或预防温血动物因手术而引起的神经损伤的方法。该发明更具体地涉及治疗或预防由前列腺手术以及勃起功能障碍引起的神经损伤的方法。
• Among the Missing: Content on Lesbian and Gay People in Social Work Journals
  作者：R. Van Voorhis、M. Wagner

  DOI：10.1093/sw/47.4.345

  日期：2002.10.1

  Lesbian and gay issues are barely visible in the social work literature. This study examined the content of articles on homosexuality that were published in four major social work journals between 1988 and 1997. Articles were coded according to their focus on either HIV/AIDS and the gay community or other issues pertaining to lesbians and gay men. Articles were also coded as client focused, worker focused, or macro focused. Two-thirds of the 77 articles published on homosexuality focused on HIV/AIDS. Most articles reflected a problem-oriented view of gay and lesbian people; few addressed heterosexism or environmental interventions. More literature is needed that focuses on strengths, heterosexist conditions, and social justice for lesbian and gay people.

  在社会工作文献中，关于同性恋和同性恋者的问题几乎没有被提及。本研究考察了1988年至1997年间在四本主要社会工作期刊上发表的关于同性恋的文章内容。文章根据关注点被编码为HIV/AIDS与同性恋社区或其他与女同性恋者和男同性恋者有关的问题。文章还被编码为以客户为中心、以工作者为中心或宏观为中心。在77篇关于同性恋的文章中，三分之二集中于HIV/AIDS。大多数文章反映了对同性恋者的以问题为导向的观点；很少有文章涉及异性恋主义或环境干预。需要更多关注同性恋者和女同性恋者优势、异性恋主义条件及社会公正的文献。
• Sequencing of peptoid peptidomimetics by Edman degradation
  作者：Astrid Boeijen、Rob M.J. Liskamp

  DOI：10.1016/s0040-4039(98)00556-5

  日期：1998.5

  The direct identification of resin-bound peptoid peptidomimetics by sequencing is described. The N-terminus of the peptoid was treated with phenyl isothiocyanate, after which the N-terminal peptoid residue was cleaved from the resin as its thiohydantoin derivative. For deduction of the peptoid sequence, the HPLC retention times of the obtained thiohydantoins were compared to those of independently

  描述了通过测序直接鉴定树脂结合的类肽拟肽。用异硫氰酸苯酯处理拟肽的N-末端，然后从树脂上裂解N-末端拟肽残基作为其硫代乙内酰脲衍生物。为了推导类肽序列，将获得的巯基乙内酰脲的HPLC保留时间与独立制备的参考巯基乙内酰脲的HPLC保留时间进行了比较。
• Hydantoin derivative compounds, pharmace utical compositions, and methods of using same
  申请人：——

  公开号：US20020058685A1

  公开（公告）日：2002-05-16

  The present invention relates generally to novel hydantoin derivative compounds, pharmaceutical compositions containing such compounds, and methods for their use in preventing and/or treating neurological disorders, including physically damaged nerves and neurodegenerative diseases; for treating alopecia and promoting hair growth; for treating vision disorders and/or improving vision; for treating memory impairment and/or enhancing memory performance; and for treating sensorineural hearing loss by administering such compounds.

  本发明涉及新型的海因唑衍生物化合物、含有该化合物的制药组合物，以及其在预防和/或治疗神经系统疾病，包括身体受损神经和神经退行性疾病；治疗脱发和促进头发生长；治疗视觉障碍和/或改善视力；治疗记忆障碍和/或增强记忆性能；以及通过给予这种化合物治疗感音神经性听力损失的方法中的应用。
• Simple and Efficient Synthesis of 5-Substituted-3-phenyl-2-thioxoimidazolidin-4-one Derivatives from<i>S</i>-Amino Acids and Phenylisothiocyanate in Et₃N/DMF-H₂O
  作者：Asha D. Jangale、Yogesh B. Wagh、Yogesh A. Tayade、Dipak S. Dalal

  DOI：10.1080/00397911.2015.1052506

  日期：2015.8.18

  A concise approach for the transformation of various S-amino acids into the 5-alkyl-3-phenyl-2-thioxoimidazolidin-4-one heterocycles using phenylisothiocyanate is described. Phenylthiohydantoins of amino acid were synthesized at room temperature in Et3N/DMF-H2O with easy workup and excellent yields.