(7ci)-n-3-吡嗪苯磺酰胺 | 875218-59-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (7ci)-n-3-吡嗪苯磺酰胺
• 英文名称: N-(Pyridazin-3-yl)benzenesulfonamide
• 英文别名: N-pyridazin-3-ylbenzenesulfonamide
• CAS: 875218-59-0
• 化学式: C₁₀H₉N₃O₂S
• 分子量: 235.26
• InChiKey: FQEBAJBGKKUVDW-UHFFFAOYSA-N

物化性质

• 沸点：
  469.7±37.0 °C(Predicted)
• 密度：
  1.425±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  80.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS<br/>[FR] COMPOSÉS DE BENZÈNESULFONAMIDE ET LEUR UTILISATION EN TANT QU'AGENTS THÉRAPEUTIQUES
  申请人：XENON PHARMACEUTICALS INC

  公开号：WO2013064983A1

  公开（公告）日：2013-05-10

  This invention is directed to benzensulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of sodium channel-mediated diseases or conditions, such as pain.

  这项发明涉及苯磺酰胺化合物，作为其立体异构体、对映异构体、互变异构体或它们的混合物；或者它们的药用可接受盐、溶剂合物或前药，用于治疗钠通道介导的疾病或症状，如疼痛。
• SULFONAMIDE DERIVATIVES
  申请人：Beaudoin Serge

  公开号：US20100197655A1

  公开（公告）日：2010-08-05

  The present invention relates to compounds of the formula and pharmaceutically acceptable salts, solvates or tautomers thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds, and the uses of such compounds, in particular for the treatment of pain.

  本发明涉及以下公式的化合物及其药学上可接受的盐、溶剂物或互变异构体，制备这些化合物的过程中使用的中间体，以及含有这些化合物的组合物，以及这些化合物的用途，特别是用于治疗疼痛。
• Sulfonamide Derivatives
  申请人：Beaudoin Serge

  公开号：US20120149679A1

  公开（公告）日：2012-06-14

  The present invention relates to compounds of the formula and pharmaceutically acceptable salts, solvates or tautomers thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds, and the uses of such compounds, in particular for the treatment of pain.

  本发明涉及以下公式的化合物及其药学上可接受的盐、溶剂合物或互变异构体，制备这些化合物的过程中使用的中间体，含有这些化合物的组合物，以及这些化合物的用途，特别是用于治疗疼痛。
• BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS
  申请人：Xenon Pharmaceuticals Inc.

  公开号：EP2773637A1

  公开（公告）日：2014-09-10
• ANIMAL MODELS, SCREENING METHODS, AND TREATMENT METHODS FOR INTRAOCULAR DISEASES OR DISORDERS
  申请人：ZHUHAI QIWEI BIO-TECHNOLOGY LTD.

  公开号：US20220015338A1

  公开（公告）日：2022-01-20

  Provided herein are screening methods and animal models related to intraocular diseases such as age-related macular degeneration (AMD), for example, for identifying candidate therapeutics for treating or preventing eye diseases, such as AMD. Also provided herein are compounds/compositions that are useful for killing or inhibiting the growth of a microorganism, such as Bacillus megaterium . Further provided herein are methods of using the compounds/compositions for treating infections with a microorganism, such as Bacillus megaterium and for treating or preventing diseases or disorders associated with such infections, such as AMD.