6-[(2R,3S)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carbonyl]oxyhexanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-[(2R,3S)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carbonyl]oxyhexanoic acid
• 化学式: C₂₂H₂₉NO₆
• 分子量: 403.5
• InChiKey: SORJFXHTZLIBBZ-QQGUTBHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  29
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  93.1
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Flagellin-based agents and uses including effective vaccination
  申请人：Genome Protection, Inc.

  公开号：US10336793B2

  公开（公告）日：2019-07-02

  The present invention relates to, in part, compositions comprising improved flagellin derived constructs and methods of using for vaccination, including adjuvants comprising flagellin-based agents.

  本发明部分涉及由改进的鞭毛蛋白衍生构建体组成的组合物和用于疫苗接种的方法，包括由鞭毛蛋白制剂组成的佐剂。
• DISRUPTED ADENOVIRUS-BASED VACCINE AGAINST DRUGS OF ABUSE
  申请人：Cornell University

  公开号：EP2547362A1

  公开（公告）日：2013-01-23
• FLAGELLIN-BASED AGENTS AND USES INCLUDING EFFECTIVE VACCINATION
  申请人：Cleveland Biolabs, Inc.

  公开号：EP3174552A1

  公开（公告）日：2017-06-07
• VACCINES FOR PREVENTION AND TREATMENT OF ADDICTION
  申请人：Crystal Ronald G.

  公开号：US20110086063A1

  公开（公告）日：2011-04-14

  The invention provides an adenovirus-antigen conjugate comprising an adenovirus with a coat protein and an antigen of an addictive drug conjugated to the coat protein of the adenovirus. The invention also provides an adenoviral vector comprising a nucleic acid sequence which encodes an antibody directed against the addictive drug. The invention further provides a method of inducing an immune response against an addictive drug or reducing the effect of an addictive drug in a human by ad-ministering to the human the aforementioned adenovirus-antigen conjugate or antibody encoding adenoviral vector.
• Induction of highly specific antibodies to a hapten but not to a carrier peptide by immunization
  申请人：Walter Reed Army Institute of Research

  公开号：US20150098935A1

  公开（公告）日：2015-04-09

  In this application Is described a composition and method for Inducing In a subject anti-hapten antibodies without Inducing antibodies to the carrier protein. Kits for designing and making compositions with desired haptens are also described. In this application Is disclosed a synthetic liposome composition comprising liposomes (L) containing monophosphoryl lipid A (MPLA) [L(MPLA)] and an immunoconjugate comprising a carrier and a hapten. In one embodiment, the carrier is a 23 amino acid hydrophobic membrane proximal external region peptide (MPER) derived from the gp41 transmembrane protein of HIV-1 that spontaneously associates with the outer surface of bilayers of liposomes containing MPLA during liposome formation.