N-[[(2S)-4-[(3,4-difluorophenyl)methyl]morpholin-2-yl]methyl]-2-[3-(methanesulfonamido)phenyl]acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[[(2S)-4-[(3,4-difluorophenyl)methyl]morpholin-2-yl]methyl]-2-[3-(methanesulfonamido)phenyl]acetamide
• 化学式: C₂₁H₂₅F₂N₃O₄S
• 分子量: 453.5
• InChiKey: AAQPHWZNFOFMHE-SFHVURJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  96.1
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• METHODS OF TREATMENT AND PREVENTION OF EYE DISEASES
  申请人：GLAXO GROUP LIMITED

  公开号：US20140335083A1

  公开（公告）日：2014-11-13

  The present invention provides compositions and methods useful for treating and preventing neovascular AMD by inhibition of CCR3. The compositions and methods are useful for treating and preventing diseases and disorders such as but not limited to, neovascular AMD

  本发明提供了一种通过抑制CCR3来治疗和预防新生血管型AMD的组合物和方法。这些组合物和方法可用于治疗和预防诸如但不限于新生血管型AMD等疾病和疾患。
• New compositions and methods of treating and/or preventing chronic obstructive pulmonary disease
  申请人：UNIVERSITE DE BORDEAUX

  公开号：EP3050574A1

  公开（公告）日：2016-08-03

  The present invention relates to a novel composition for the treatment and/or the prevention of chronic obstructive pulmonary disease (COPD) and acute exacerbations of chronic obstructive pulmonary disease (AECOPD).

  本发明涉及一种用于治疗和/或预防慢性阻塞性肺病（COPD）和慢性阻塞性肺病急性加重（AECOPD）的新型组合物。
• CHEMOKINE RECEPTOR CXCR4 INHIBITORS FOR TREATING AND/OR PREVENTING CHRONIC OBSTRUCTIVE PULMONARY DISEASE
  申请人：UNIVERSITE DE BORDEAUX

  公开号：EP3613435A1

  公开（公告）日：2020-02-26

  The present invention relates to a novel composition for the treatment and/or the prevention of chronic obstructive pulmonary disease (COPD) and acute exacerbations of chronic obstructive pulmonary disease (AECOPD).

  本发明涉及一种用于治疗和/或预防慢性阻塞性肺病（COPD）和慢性阻塞性肺病急性加重（AECOPD）的新型组合物。
• Methods of treating and/or preventing chronic obstructive pulmonary disease
  申请人：UNIVERSITE DE BORDEAUX

  公开号：US10813911B2

  公开（公告）日：2020-10-27

  The present invention relates to a novel composition or method of use for the treatment and/or the prevention of chronic obstructive pulmonary disease (COPD) and acute exacerbations of chronic obstructive pulmonary disease (AECOPDs).

  本发明涉及一种用于治疗和/或预防慢性阻塞性肺病（COPD）和慢性阻塞性肺病急性加重（AECOPDs）的新型组合物或使用方法。
• N-2s-4-3,4-difluorobenzyl morpholin-2yl methyl -2-(3-methylsulphonyl amino!phenyl acetamide as ccr3 antagonist for the treatment of inflammatory conditions
  申请人：Ancliff Ann Rachael

  公开号：US20060058299A1

  公开（公告）日：2006-03-16

  Compound of formula (I): and salts and solvates thereof, a process for its preparation, pharmaceutical formulations containing it and its use in therapy.

  式 (I) 的化合物： 及其盐类和溶解物、制备方法、含有该化合物的药物制剂和治疗用途。