2-((1R,3S)-3-{2-[3-butyl-1-(4-methylbenzyl)ureido]ethoxy}-cyclohexyloxymethyl)-6-methylbenzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-((1R,3S)-3-{2-[3-butyl-1-(4-methylbenzyl)ureido]ethoxy}-cyclohexyloxymethyl)-6-methylbenzoic acid
• 英文别名: 2-[[(1R,3S)-3-[2-[butylcarbamoyl-[(4-methylphenyl)methyl]amino]ethoxy]cyclohexyl]oxymethyl]-6-methylbenzoic acid
• 化学式: C₃₀H₄₂N₂O₅
• 分子量: 510.674
• InChiKey: MGHQUKHLMYXDHN-RRPNLBNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  37
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  88.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Arylcycloalkyl derivatives having branched side chains, processes for their preparation and their use as pharmaceuticals
  申请人：Aventis Pharma Deutschland GmbH

  公开号：US20040209873A1

  公开（公告）日：2004-10-21

  Arylcycloalkyl derivatives having branched side chains, processes for their preparation and their use as pharmaceuticals The invention relates to arylcycloalkyl derivatives having branched side chains and to their physiologically acceptable salts and physiologically functional derivatives. What is described are compounds of the formula I, 1 in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistence is involved.

  含有分支侧链的芳基环烷衍生物、其制备方法以及作为药物的用途。该发明涉及具有分支侧链的芳基环烷衍生物及其生理上可接受的盐和生理功能衍生物。描述的是符合以下公式I的化合物，其中基团如定义所示，以及它们的生理上可接受的盐和制备方法。这些化合物适用于治疗和/或预防脂肪酸代谢紊乱、葡萄糖利用紊乱以及胰岛素抵抗相关疾病。
• US7220876B2
  申请人：——

  公开号：US7220876B2

  公开（公告）日：2007-05-22