(3-{3-[(2,4-bis-trifluoromethyl-benzyl)-(5-ethyl-pyrimidin-2-yl)-amino]-propoxy}-phenyl)-acetic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-{3-[(2,4-bis-trifluoromethyl-benzyl)-(5-ethyl-pyrimidin-2-yl)-amino]-propoxy}-phenyl)-acetic acid
• 英文别名: 2-[3-[3-[[2,4-Bis(trifluoromethyl)phenyl]methyl-(5-ethylpyrimidin-2-yl)amino]propoxy]phenyl]acetic acid
• 化学式: C₂₆H₂₅F₆N₃O₃
• 分子量: 541.493
• InChiKey: DDPRWGGIDVSHDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  38
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  75.6
• 氢给体数：
  1
• 氢受体数：
  12

文献信息

• (3-{3-'(2,4-BIS-TRIFLUORMETHYL-BENZYL)-(5-ETHYL-PYRIMIDIN-2-YL)-AMINO]-PROPOXY}-PHENYL)-ACETIC ACID AND RELATED COMPOUNDS AS MODULATORS OF PPARS AND METHODS OF TREATING METABOLIC DISORDERS
  申请人：Kalypsys, Inc.

  公开号：EP1613326B1

  公开（公告）日：2006-09-13
• Aryl compounds as modulators of PPARS and methods of treating metabolic disorders
  申请人：Liu Kevin

  公开号：US20050070532A1

  公开（公告）日：2005-03-31

  Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
• METHODS FOR THE SELECTIVE MODULATION OF PPAR
  申请人：Shiau K. Andrew

  公开号：US20070190079A1

  公开（公告）日：2007-08-16

  The present invention relates to methods of selective modulation of peroxisome proliferator activated receptors (PPARs) over G-protein coupled receptor 40 (GPR40), and the use of therapeutically effective amounts of compounds and pharmaceutical compositions which selectively modulate PPAR over GPR40 for the treatment of diseases in patients in need thereof. The methods disclosed herein are exceptionally useful in treating metabolic diseases whilst avoiding certain side effects common to modulators of PPAR previously disclosed in the art.