[2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl]-[6-(4-phenylbutoxy)hexyl]azanium;(E)-3-(4-phenylphenyl)prop-2-enoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl]-[6-(4-phenylbutoxy)hexyl]azanium;(E)-3-(4-phenylphenyl)prop-2-enoate
• 化学式: C40H49NO6
• 分子量: 639.8
• InChiKey: JDXIKHSKBFHPSA-IBMQDACXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.56
• 重原子数：
  47
• 可旋转键数：
  19
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  119
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• Pharmaceutical compositions for inhalation containing an anticholinergic, corticosteroid and betamimetic
  申请人：Boehringer Ingelheim Pharma GmbH & Co. KG

  公开号：US20040228805A1

  公开（公告）日：2004-11-18

  A pharmaceutical composition comprising: (a) an anticholinergic of formula 1 1 wherein X− is an anion with a single negative charge; (b) a corticosteroid; and (c) a betamimetic, wherein each component (a), (b), and (c) are optionally in the form of the solvates or hydrates thereof, processes for preparing them, and their use in the treatment of respiratory diseases.

  一种药物组合物，包括 (a) 式 1 的抗胆碱能药物 1 其中 X- 是带单个负电荷的阴离子； (b) 一种皮质类固醇；和 (c) 一种拟贝特类药物、 其中各组分(a)、(b)和(c)可选择以其溶物或水合物的形式存在，其制备工艺及其在治疗呼吸系统疾病中的用途。
• Pharmaceutical Compositions for Inhalation Containing an Anticholinergic, Corticosteroid, and Betamimetic
  申请人：Pieper Paul Michael

  公开号：US20080063608A1

  公开（公告）日：2008-03-13

  A pharmaceutical composition comprising: (a) an anticholinergic of formula 1 wherein X − is an anion with a single negative charge; (b) a corticosteroid; and (c) a betamimetic, wherein each component (a), (b), and (c) are optionally in the form of the solvates or hydrates thereof, processes for preparing them, and their use in the treatment of respiratory diseases.
• US7244742B2
  申请人：——

  公开号：US7244742B2

  公开（公告）日：2007-07-17