trans-4-({[(2R,4S,5S)-6-(3,5-difluorophenyl)-5-({[3-(dipropylcarbamoyl)phenyl]carbonyl}amino)-2-ethyl-4-hydroxyhexanoyl]amino}methyl)cyclohexanecarboxylic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: trans-4-({[(2R,4S,5S)-6-(3,5-difluorophenyl)-5-({[3-(dipropylcarbamoyl)phenyl]carbonyl}amino)-2-ethyl-4-hydroxyhexanoyl]amino}methyl)cyclohexanecarboxylic acid
• 英文别名: 4-[[[(2R,4S,5S)-6-(3,5-difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-2-ethyl-4-hydroxyhexanoyl]amino]methyl]cyclohexane-1-carboxylic acid
• 化学式: C₃₆H₄₉F₂N₃O₆
• 分子量: 657.8
• InChiKey: YRTFQCVTZROZMF-UPIFRUPESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  47
• 可旋转键数：
  17
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  136
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Methods to treat alzheimer's disease
  申请人：——

  公开号：US20020019403A1

  公开（公告）日：2002-02-14

  The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) 1 useful in treating Alzheimer's disease and other similar diseases.

  本发明涉及用于治疗阿尔茨海默病和其他类似疾病的式（XII）1中的替代羟乙烯化合物。
• Compounds to treat Alzheimer's disease
  申请人：Elan Pharmaceuticals, Inc.

  公开号：US20040214846A1

  公开（公告）日：2004-10-28

  The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) 1 useful in treating Alzheimer's disease and other similar diseases.

  本发明涉及式（XII）的取代羟基乙烯化合物，可用于治疗阿尔茨海默病和其他类似疾病。
• Compounds to treat alzheimer's disease
  申请人：——

  公开号：US20020022623A1

  公开（公告）日：2002-02-21

  The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) 1 useful in treating Alzheimer's disease and other similar diseases.

  本发明涉及用于治疗阿尔茨海默病和其他类似疾病的式（XII）1的取代羟基乙烯化合物。
• Methods to Treat Alzheimer's Disease
  申请人：Hom Roy

  公开号：US20080058336A1

  公开（公告）日：2008-03-06

  The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases.

  本发明涉及一种式子为(XII)的取代羟乙烯化合物，用于治疗阿尔茨海默病和其他类似疾病。
• COMPOUNDS AND METHODS TO TREAT ALZHEIMER'S DISEASE
  申请人：ELAN PHARMACEUTICALS, INC.

  公开号：EP1265849B1

  公开（公告）日：2006-10-25