4-[N-(4-methoxyphenyl)-N-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]amino]-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-[N-(4-methoxyphenyl)-N-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]amino]-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine
• 英文别名: N-(4-methoxyphenyl)-N,1-bis[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidin-4-amine
• 化学式: C₄₂H₄₈N₄O₇
• 分子量: 720.866
• InChiKey: FCMRKIJWSJURDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  53
• 可旋转键数：
  15
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  96.9
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  4-[N-(4-methoxyphenyl)-N-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]amino]-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine 生成 4-[N-(4-methoxyphenyl)-N-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]amino]-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine trihydrochloride
  参考文献：
  名称：

  EP1568691

  摘要：

  公开号：

文献信息

• Medicine for treating cancer
  申请人：Mataki Chikage

  公开号：US20050176764A1

  公开（公告）日：2005-08-11

  Abstract The present invention is directed to a method for treating cancer, a method for inhibiting histone deacetylase, and a method for facilitating gene therapy, comprising administering an effective amount of a cyclic amine compound represented by the following formula (1):(wherein R1, R2, and R3 each independently represent a hydrogen atom, a halogen atom, a hydroxy group, an alkyl group, a halogen-substituted alkyl group, an alkoxy group, an alkylthio group, a carboxyl group, an alkoxycarbonyl group, or an alkanoyl group; W1 and W2, which are identical to or different from each other, represent N or CH; X represents O, NR4, CONR4, or NR4CO; R4 represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted heteroaralkyl group; and l, m, and n each represent a number of 0 or 1), a salt thereof, or a hydrate thereof.208

  本发明涉及一种治疗癌症、抑制组蛋白去乙酰化酶和促进基因治疗的方法，包括给予下式（1）所表示的环状胺化合物的有效量：（其中R1、R2和R3各自独立地表示氢原子、卤素原子、羟基、烷基、卤代烷基、烷氧基、烷硫基、羧基、烷氧羰基或烷酰基；W1和W2相同或不同，表示N或CH；X表示O、NR4、CONR4或NR4CO；R4表示氢原子、烷基、烯基、炔基、取代或未取代芳基、取代或未取代杂环芳基、取代或未取代芳基烷基、取代或未取代杂环芳基烷基；l、m和n各自表示0或1的数字），其盐或水合物。
• ERYTHROPOIETIN PRODUCTION ACCELERATOR
  申请人：IMAGAWA Shigehiko

  公开号：US20090143430A1

  公开（公告）日：2009-06-04

  The present invention relates to a preventive or therapeutic agent for pathological conditions caused by reduced production of erythropoietin, or for anemia, or for chronic anemia, renal anemia, aplastic anemia, or pure red cell aplasia, the agent comprising, as an active ingredient, a cyclic amine compound represented by the following formula (1): wherein, R 1 , R 2 and R 3 each independently represent a hydrogen atom, a halogen atom, or hydroxy, alkyl, halogen-substituted alkyl, alkoxy, alkylthio, carboxyl, alkoxycarbonyl or alkanoyl group; W 1 and W 2 each independently represent N or CH; X represents O, NR 4 , CONR 4 or NR 4 CO; R 4 each represents a hydrogen atom, or an alkyl, alkenyl, alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, or substituted or unsubstituted heteroaralkyl group; and l, m and n each represents a number of 0 or 1, or a salt thereof or a solvate thereof.

  本发明涉及一种预防或治疗因红细胞生成素减少引起的病理状况，或用于贫血、慢性贫血、肾性贫血、再生障碍性贫血或纯红细胞再生障碍的药物。该药物包含以下式子（1）所表示的环状胺化合物作为活性成分：其中，R1、R2和R3各自独立地表示氢原子、卤素原子、羟基、烷基、卤代烷基、烷氧基、烷硫基、羧基、烷氧羰基或烷酰基基团；W1和W2各自独立地表示N或CH；X表示O、NR4、CONR4或NR4CO；R4表示氢原子、或烷基、烯基、炔基、取代或未取代芳基、取代或未取代杂环芳基、取代或未取代芳基烷基、取代或未取代杂环芳基烷基基团；l、m和n各自表示0或1的数字，或其盐或溶剂。
• ANGIOGENESIS INHIBITOR
  申请人：Kowa Co., Ltd.

  公开号：EP1674100A1

  公开（公告）日：2006-06-28

  The present invention relates to a prophylactic or therapeutic agent against a disease or pathological condition caused by angiogenesis, comprising, as an active ingredient, a cyclic amine compound represented by the general formula (1): wherein R1, R2, and R3 each independently represent a hydrogen atom, a halogen atom, a hydroxy group, an alkyl group, a halogen-substituted alkyl group, an alkoxy group, an alkylthio group, a carboxyl group, an alkoxycarbonyl group, or an alkanoyl group; W1 and W2 each independently represent N or CH; X represents O, NR4, CONR4, -or NR9-CO; R4 represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted heteroaralkyl group; and l, m, and n each represent a number of 0 or 1, or a salt thereof, or a solvate thereof.

  本发明涉及一种针对由血管生成引起的疾病或病理状态的预防或治疗剂，其活性成分包括由通式（1）代表的环胺化合物： 其中 R1、R2 和 R3 各自独立地代表氢原子、卤素原子、羟基、烷基、卤素取代的烷基、烷氧基、烷硫基、羧基、烷氧羰基或烷酰基；W1 和 W2 各自独立地代表 N 或 CH；X 代表 O、NR4、CONR4、-或 NR9-CO；R4代表氢原子、烷基、烯基、炔基、取代或未取代的芳基、取代或未取代的杂芳基、取代或未取代的芳烷基或取代或未取代的杂芳基；以及 l、m 和 n 各自代表 0 或 1，或其盐，或其溶液。
• MEDICINE FOR TREATING CANCER
  申请人：Kowa Co., Ltd.

  公开号：EP1494670A1

  公开（公告）日：2005-01-12
• Angiogenesis inhibitor
  申请人：Doi Takeshi

  公开号：US20070043078A1

  公开（公告）日：2007-02-22

  The present invention relates to a prophylactic or therapeutic agent against a disease or pathological condition caused by angiogenesis, comprising, as an active ingredient, a cyclic amine compound represented by the general formula (1): wherein R 1 , R 2 , and R 3 each independently represent a hydrogen atom, a halogen atom, a hydroxy group, an alkyl group, a halogen-substituted alkyl group, an alkoxy group, an alkylthio group, a carboxyl group, an alkoxycarbonyl group, or an alkanoyl group; W 1 and W 2 each independently represent N or CH; X represents O, NR 4 , CONR 4 , or NR 4 CO; R 4 represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted heteroaralkyl group; and l, m, and n each represent a number of 0 or 1, or a salt thereof, or a solvate thereof.