3,4-dihydroxy-5-hydroxymethyl-N-benzyl-2-pyrrolidone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,4-dihydroxy-5-hydroxymethyl-N-benzyl-2-pyrrolidone
• 英文别名: 1-Benzyl-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-one
• 化学式: C₁₂H₁₅NO₄
• 分子量: 237.255
• InChiKey: NDEVUJFZDBBDQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  81
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Process and intermediate compounds for the preparation of pyrrolidines
  申请人：Michigan State University Board of Trustees operating

  公开号：US20020019542A1

  公开（公告）日：2002-02-14

  Processes for the preparation of pyrrolidones (7 and 8) and pyrrolidines (9 and 10) from tri-O-acetyl-D-erythro-4-pentulosonic acid esters are described. The compounds are aza sugar analogs of D-ribofuranoside and are intermediates to drugs which regulate nucleoside and nucleic acid synthesis.

  本文描述了从三-O-乙酰-D-erythro-4-戊糖酸酯制备吡咯烷酮（7和8）和吡咯烷（9和10）的过程。这些化合物是D-核糖呋喃苷的氮杂糖类似物，是调节核苷酸和核酸合成的药物的中间体。
• Oximes or imines of 4-pentulosonic acid methyl esters as intermediates for the preparation of pyrrolidines
  申请人：Michigan State University

  公开号：EP1947082A2

  公开（公告）日：2008-07-23

  Processes for the preparation of pyrrolidones (7 and 8) and pyrrolidines (9 and 10) from tri-O-acetyl-D-erythro-4-pentulonsonic acid esters are described. The compounds are aza sugar analogs of D-ribofuranoside and are intermediates to drugs which regulate nucleoside and nucleic acid synthesis.

  描述了从三-O-乙酰基-D-赤式-4-戊磺酸酯制备吡咯烷酮（7 和 8）和吡咯烷（9 和 10）的工艺。这些化合物是 D-呋喃核苷的偶氮糖类似物，是调节核苷和核酸合成药物的中间体。
• 2-Pyrrolidones as intermediates for the preparation of pyrrolidines
  申请人：Michigan State University

  公开号：EP1947084A2

  公开（公告）日：2008-07-23

  Processes for the preparation of pyrrolidones (7 and 8) and pyrrolidines (9 and 10) from tri-O-acetyl-D-erythro-4-pentulonsonic acid esters are described. The compounds are aza sugar analogs of D-ribofuranoside and are intermediates to drugs which regulate nucleoside and nucleic acid synthesis.

  描述了从三-O-乙酰基-D-赤式-4-戊磺酸酯制备吡咯烷酮（7 和 8）和吡咯烷（9 和 10）的工艺。这些化合物是 D-呋喃核苷的偶氮糖类似物，是调节核苷和核酸合成药物的中间体。
• PROCESS AND INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF PYRROLIDINES
  申请人：MICHIGAN STATE UNIVERSITY

  公开号：EP1305284A1

  公开（公告）日：2003-05-02
• EP1305284A4
  申请人：——

  公开号：EP1305284A4

  公开（公告）日：2005-08-03