1-[8-(4-chloro-3-nitrophenyl)-3,4,5,8-tetrahydro-6-methyl-1,1-dioxido-2H-thiopyrano[3,2-b]pyridin-7-yl]ethan-1-one | 227609-18-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[8-(4-chloro-3-nitrophenyl)-3,4,5,8-tetrahydro-6-methyl-1,1-dioxido-2H-thiopyrano[3,2-b]pyridin-7-yl]ethan-1-one
• 英文别名: 1-[8-(4-chloro-3-nitrophenyl)-3,4,5,8-tetrahydro-6-methyl-1,1-dioxido-2H-thiopyrano[3,2-b]pyridin-7-yl]ethanone；1-[8-(4-chloro-3-nitrophenyl)-6-methyl-1,1-dioxo-3,4,5,8-tetrahydro-2H-thiopyrano[3,2-b]pyridin-7-yl]ethanone
• CAS: 227609-18-9
• 化学式: C₁₇H₁₇ClN₂O₅S
• 分子量: 396.851
• InChiKey: GYOUARGCPLTMJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  117
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Potassium channel openers
  申请人：——

  公开号：US20010036950A1

  公开（公告）日：2001-11-01

  Compounds having the formula 1 are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

  具有公式1的化合物在治疗由钾通道开放剂预防或缓解的疾病中很有用。还公开了开放钾通道的组合物和在哺乳动物中开放钾通道的方法。
• POTASSIUM CHANNEL OPENERS
  申请人：Abbott Laboratories

  公开号：EP1040097B1

  公开（公告）日：2004-04-14
• US6265417B1
  申请人：——

  公开号：US6265417B1

  公开（公告）日：2001-07-24
• US6593335B1
  申请人：——

  公开号：US6593335B1

  公开（公告）日：2003-07-15
• [EN] POTASSIUM CHANNEL OPENERS<br/>[FR] AGENTS D'OUVERTURE DE CANAL POTASSIQUE
  申请人：ABBOTT LAB

  公开号：WO2000078768A1

  公开（公告）日：2000-12-28

  Compounds having formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.