3-(2,5-difluorophenyl)-N-[N-[3-(2,5-difluorophenyl)-2-methylpropanoyl]carbamimidoyl]-2-methylpropanamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(2,5-difluorophenyl)-N-[N-[3-(2,5-difluorophenyl)-2-methylpropanoyl]carbamimidoyl]-2-methylpropanamide
• 化学式: C₂₁H₂₁F₄N₃O₂
• 分子量: 423.4
• InChiKey: NVECSOZSUGPVIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  84.6
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Diacyl-substituted guanidines, a process for their preparation, their use as medicament or diagnostic aid, and medicament containing them
  申请人：Hoechst Aktiengesellschaft

  公开号：US20040044081A1

  公开（公告）日：2004-03-04

  Diacyl-substituted guanidines, a process for their preparation, their use as medicament or diagnostic aid, and medicament containing them. Diacyl-substituted guanidines of the formula I 1 are described where X(1) and X(2) are 2 T1 is zero, 1, 2, 3 or 4, R(A) and R(B) are hydrogen, Hal, CN, OR(106), (O) (cyclo)—(fluoro)alkyl, NR(107)R(108), phenyl or benzyl, or 3 T2a and T2b are, independently of each other, zero, 1 or 2, where the double bond can be in the E or Z configuration; or X(1) and X(2) are 4 as are the pharmaceutically tolerated salts thereof. They are outstandingly suitable for use as antiarrhythmic pharmaceuticals possessing a cardioprotective component for the prophylaxis and treatment of infarction and for the treatment of angina pectoris, in connection with which they also inhibit or strongly reduce, in a preventive manner, the pathophysiological processes associated with the genesis of ischemically induced damage, in particular associated with the elicitation of ischemically induced cardiac arrhythmias. On account of their protective effects against pathological hypoxic and ischemic situations, the compounds of the formula I according to the invention can, as a consequence of inhibiting the cellular Na + /H + exchange mechanism, be used as pharmaceuticals for treating all acute or chronic damage elicited by ischemia, or diseases induced primarily or secondarily thereby.

  Diacyl-取代的胍类化合物的制备方法，它们的用途作为药物或诊断辅助剂，以及含有它们的药物。描述了式I1的Diacyl-取代的胍类化合物，其中X（1）和X（2）为2T1为零，1、2、3或4，R（A）和R（B）为氢，Hal，CN，OR（106），（O）（环） - （氟）烷基，NR（107）R（108），苯基或苄基，或3T2a和T2b独立地为零、1或2，其中双键可以处于E或Z构型；或X（1）和X（2）为4，以及其药物耐受的盐。它们非常适合用作具有心脏保护成分的抗心律失常药物，用于预防和治疗梗塞和心绞痛，在这种情况下，它们还可以以预防性的方式抑制或强烈减少与缺血性损伤的发生有关的病理生理过程，特别是与缺血性诱导的心脏心律失常有关。由于它们对病理性低氧和缺血情况的保护作用，根据本发明的I式化合物可以通过抑制细胞Na+/H+交换机制作为药物用于治疗由缺血引起的所有急性或慢性损伤，或由此引起的主要或次要疾病。
• US6436999B1
  申请人：——

  公开号：US6436999B1

  公开（公告）日：2002-08-20
• US6632840B1
  申请人：——

  公开号：US6632840B1

  公开（公告）日：2003-10-14