N-(4-aminocyclohexyl)-3-chloro-N-[[3-(4-cyanophenyl)-4-methoxyphenyl]methyl]-1-benzothiophene-2-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-aminocyclohexyl)-3-chloro-N-[[3-(4-cyanophenyl)-4-methoxyphenyl]methyl]-1-benzothiophene-2-carboxamide
• 化学式: C₃₀H₂₈ClN₃O₂S
• 分子量: 530.1
• InChiKey: DHIDPDXIMZFIAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  37
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Therapeutic Use of Activators of Zinc Finger Protein GL13
  申请人：Universtität Leipzig

  公开号：US20140336111A1

  公开（公告）日：2014-11-13

  The present invention relates to the therapeutic use of activators of the zinc finger protein GLI3 in diseases that are associated with reduced Hedgehog signaling in hepatocytes, in particular Polycystic ovary syndrome, Steatosis hepatis, Steatohepatit is and/or Adipositas. The invention further relates to methods of treating an individual with said activator, a pharmaceutical composition comprising said activator and the use of said activator as food supplement.
• COMPOSITION, USES, AND METHODS OF TREATING SPINAL DISC DEGENERATION THROUGH SONIC HEDGEHOG SIGNALING PATHWAY
  申请人：New York Society for the Ruptured and Crippled Maintaining the Hospital for Special Surgery

  公开号：US20210128540A1

  公开（公告）日：2021-05-06

  Presented herein are methods for treating spinal disc degeneration (SDD) by administering to a subject in need thereof, an amount of a SHE signaling pathway activator effective for treating the subject.
• US9540648B2
  申请人：——

  公开号：US9540648B2

  公开（公告）日：2017-01-10