6-{3-[benzothiazol-2-yl-(2,4-bis-trifluoromethyl-benzyl)-amino]-propoxy}-pyridine-2-carboxylic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-{3-[benzothiazol-2-yl-(2,4-bis-trifluoromethyl-benzyl)-amino]-propoxy}-pyridine-2-carboxylic acid
• 英文别名: 6-[3-[1,3-Benzothiazol-2-yl-[[2,4-bis(trifluoromethyl)phenyl]methyl]amino]propoxy]pyridine-2-carboxylic acid
• 化学式: C₂₅H₁₉F₆N₃O₃S
• 分子量: 555.501
• InChiKey: GSHAJBCYXRQNEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  38
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  104
• 氢给体数：
  1
• 氢受体数：
  13

文献信息

• N-Containing Heteroaromatic Compounds As Modulators Of Ppars And Methods Of Treating Metabolic Disorders
  申请人：Liu Kevin

  公开号：US20070208026A1

  公开（公告）日：2007-09-06

  Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
• [EN] N-CONTAINING HETEROAROMATIC COMPOUNDS AS MODULATORS OF PPARS AND METHODS OF TREATING METABOLIC DISORDERS<br/>[FR] COMPOSES HETEROAROMATIQUES CONTENANT N EN TANT QUE MODULATEURS DE PPARS ET METHODES POUR TRAITER DES TROUBLES DU METABOLISME
  申请人：KALYPSYS INC

  公开号：WO2004092130A2

  公开（公告）日：2004-10-28

  Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed, (I) wherein (i) is a monocyclicic or biclyclic aromatic moiety in which at least one of the ring atoms is N and selected from the group consisting of (ii), (iii), (iv), (v), and (vi); L is selected from the group consisting of a bond and CH2.