(R)-(+)-2-(苯基氨基甲酰氧基)丙酸 | 145987-00-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (R)-(+)-2-(苯基氨基甲酰氧基)丙酸
• 中文别名: (R)-2-[(苯基氨基)羰基氧基]丙酸；(R)-(+)-2-[丙氨基羰酰氧基]丙酸
• 英文名称: (R)-(+)-2-(Phenylcarbamoyloxy)propionic acid
• 英文别名: (2R)-2-(phenylcarbamoyloxy)propanoic acid
• CAS: 145987-00-4
• 化学式: C₁₀H₁₁NO₄
• mdl: MFCD00158473
• 分子量: 209.2
• InChiKey: HYIHYWQSOXTJFS-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38

文献信息

• NOVEL PROCESSES FOR THE PREPARATION OF PHENYLCYCLOPROPYLAMINE DERIVATIVES AND USE THEREOF FOR PREPARING TICAGRELOR
  申请人：Khile Anil Shahaji

  公开号：US20130165696A1

  公开（公告）日：2013-06-27

  Provided herein are novel processes for the preparation of phenylcyclopropylamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein are novel, commercially viable and industrially advantageous processes for the preparation of a substantially pure ticagrelor intermediate, trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine. Provided further herein are novel acid addition salts of trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine, and process for their preparation. The intermediate and its acid addition salts are useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof, in high yield and purity.

  本文提供了一种制备苯基环丙胺衍生物的新型工艺，这些衍生物在三唑并[4,5-d]嘧啶化合物的制备中是有用的中间体。特别提供了一种新颖、商业可行且在工业上具有优势的工艺，用于制备一种基本纯的替卡格雷中间体，即trans-(1R,2S)-2-(3,4-二氟苯基)-环丙胺。此外，本文还提供了trans-(1R,2S)-2-(3,4-二氟苯基)-环丙胺的新型酸加盐，以及其制备工艺。该中间体及其酸加盐对于高产率和纯度制备替卡格雷或其药用可接受盐是有用的。
• NOVEL PROCESS FOR PREPARING PHENYLCYCLOPROPYLAMINE DERIVATIVES USING NOVEL INTERMEDIATES
  申请人：Khile Anil Shahaji

  公开号：US20130150577A1

  公开（公告）日：2013-06-13

  Provided herein is a novel process for the preparation of phenylcyclopropylamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of a substantially pure ticagrelor intermediate, trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine. The intermediate is useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof, in high yield and purity.

  本文提供了一种新颖的制备苯基环丙胺衍生物的过程，这些衍生物在三唑并[4,5-d]嘧啶化合物的制备中是有用的中间体。特别提供了一种新颖的、商业可行且在工业上具有优势的过程，用于制备一种基本纯净的替卡格雷中间体，即trans-(1R,2S)-2-(3,4-二氟苯基)-环丙胺。该中间体可用于高产率和纯度地制备替卡格雷或其药学上可接受的盐。
• Novel process and intermediates 085
  申请人：Hedberg Martin

  公开号：US20070270487A1

  公开（公告）日：2007-11-22

  The present invention relates to a novel process suitable for large-scale production of phenyl propane derivatives as well as to novel intermediates in the process.

  本发明涉及一种适用于苯丙烷衍生物大规模生产的新工艺，以及在该过程中的新中间体。
• NOVEL PROCESSES FOR PREPARING TRIAZOLO[4, 5-d]PYRIMIDINE DERIVATIVES AND INTERMEDIATES THEREOF
  申请人：Nair Vignesh

  公开号：US20130317220A1

  公开（公告）日：2013-11-28

  Provided herein is a novel process for the preparation of triazolo[4,5-d]pyrimidine derivatives. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of highly pure ticagrelor or a pharmaceutically acceptable salt thereof. Provided further herein is a novel process for the preparation of substituted cyclopentanamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of a ticagrelor intermediate, 2-[[(3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]-dioxol-4-yl]oxy]-1-ethanol.

  本文提供了一种新型的三唑并[4,5-d]嘧啶衍生物制备方法。特别提供了一种新型、商业可行和工业上优劣势明显的制备高纯度替卡格雷洛或其药学可接受盐的方法。此外，本文还提供了一种制备取代环戊胺衍生物的新方法，这些衍生物在制备三唑并[4,5-d]嘧啶化合物中是有用的中间体。特别提供了一种新型、商业可行和工业上优劣势明显的制备替卡格雷洛中间体2-[[(3aR,4S,6R,6aS)-6-氨基-2,2-二甲基四氢-3aH-环戊[d][1,3]-二氧杂环-4-基]氧基]-1-乙醇的方法。
• NOVEL PROCESSES FOR PREPARING TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES AND INTERMEDIATES THEREOF
  申请人：Actavis Group Ptc Ehf

  公开号：EP2655341A2

  公开（公告）日：2013-10-30