N-diaminobenzidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-diaminobenzidine
• 英文别名: 4-[4-(diaminoamino)phenyl]aniline
• 化学式: C₁₂H₁₄N₄
• 分子量: 214.27
• InChiKey: OFAQDRFVUJMWGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  81.3
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Method of diagnosing bladder cancer
  申请人：Oncotherapy Science, Inc.

  公开号：EP2011885B1

  公开（公告）日：2015-04-22
• METHODS OF SCREENING FOR AGENTS THAT INHIBIT BINDING BETWEEN MPHOSPH1 AND PRC1
  申请人：Oncotherapy Science, Inc.

  公开号：EP2059812A1

  公开（公告）日：2009-05-20
• METHOD OF DIAGNOSING BLADDER CANCER
  申请人：Nakamura Yusuke

  公开号：US20090175844A1

  公开（公告）日：2009-07-09

  Objective methods for detecting and diagnosing bladder cancer (BLC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of a BLC-associated gene that discriminates between BLC cells and normal cells. The present invention further provides means for predicting and preventing bladder cancer metastasis using BLC-associated genes having unique altered expression patterns in bladder cancer cells with lymph-node metastasis. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of bladder cancer, methods of treating bladder cancer and method for vaccinating a subject against bladder cancer. In particular, the present application provides novel human genes C2093, B5860Ns and C6055s whose expression is markedly elevated in bladder cancers. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of bladder cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of bladder cancer.
• US7998695B2
  申请人：——

  公开号：US7998695B2

  公开（公告）日：2011-08-16
• [EN] METHODS OF SCREENING FOR AGENTS THAT INHIBIT BINDING BETWEEN MPHOSPH1 AND PRC1<br/>[FR] MÉTHODES DE SÉLECTION D'AGENTS QUI INHIBENT LA LIAISON ENTRE MPHOSPH1 ET PRC1
  申请人：ONCOTHERAPY SCIENCE INC

  公开号：WO2008023842A1

  公开（公告）日：2008-02-28

  [EN] The present invention provides a method of identifying agents that inhibit or suppress the binding between MPHOSPH1 and PRC1. Such agents are expected to suppress the proliferation of cell expressing MPHOSPH1 and PRC1, and function as agents to prevent or treat cancer, such as bladder cancer.
  [FR] La présente invention porte sur une méthode d'identification d'agents qui inhibent ou suppriment la liaison entre MPHOSPH1 et PRC1. Ces agents sont susceptibles de supprimer la prolifération de cellules exprimant MPHOSPH1 et PRC1, et agissent comme des agents de prévention ou de traitement du cancer tel que le cancer de la vessie.