N-(3-carbamoylphenyl)-N'-(2-hydroxy-5-chlorophenyl) urea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-carbamoylphenyl)-N'-(2-hydroxy-5-chlorophenyl) urea
• 英文别名: 3-[(5-Chloro-2-hydroxyphenyl)carbamoylamino]benzamide
• 化学式: C₁₄H₁₂ClN₃O₃
• 分子量: 305.721
• InChiKey: LUMXEJZMDAYVSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  104
• 氢给体数：
  4
• 氢受体数：
  3

文献信息

• Diphenylurea Derivatives Useful As Potassium Channel Activators
  申请人：Dahl H. Bjarne

  公开号：US20070293553A1

  公开（公告）日：2007-12-20

  The present invention relates to the medical use of a certain group of diphenyl urea derivatives as potassium channel blockers for treating cardiovascular diseases, an obstructive or inflammatory airway disease, urinary incontinence, psychosis, epilepsy or pain, or for facilitating the blood-brain barrier permeability for other therapeutic substances. In other aspects the invention relates to the use of these compounds in a method of therapy.

  本发明涉及使用某些二苯基脲衍生物作为钾通道阻滞剂，用于治疗心血管疾病、阻塞性或炎性气道疾病、尿失禁、精神病、癫痫或疼痛，或用于促进其他治疗物质通过血脑屏障的渗透。在其他方面，本发明涉及这些化合物在治疗方法中的使用。
• Compounds for use in disorders associated with mast cell or basophil acitvity
  申请人：Madsen Siim Lars

  公开号：US20050080112A1

  公开（公告）日：2005-04-14

  The present invention relates to the use certain compounds for the treatment, prevention or alleviation of a disorder or disease of a subject, which disorder or disease is responsive to modulation of the mast cell or basophil activity of such a subject.

  本发明涉及使用某些化合物来治疗、预防或减轻受试者的失调或疾病，这种失调或疾病对调节受试者肥大细胞或嗜碱性粒细胞的活性有反应。
• UREA AND AMIDE DERIVATIVES AND THEIR USE IN THE CONTROL OF CELL MEMBRANE POTASSIUM CHANNELS
  申请人：NEUROSEARCH A/S

  公开号：EP0693053A1

  公开（公告）日：1996-01-24
• US5696138A
  申请人：——

  公开号：US5696138A

  公开（公告）日：1997-12-09
• [EN] UREA AND AMIDE DERIVATIVES AND THEIR USE IN THE CONTROL OF CELL MEMBRANE POTASSIUM CHANNELS<br/>[FR] DERIVES UREIQUES ET AMIDIQUES ET LEUR UTILISATION DANS LA REGULATION DES CANAUX A POTASSIUM DES MEMBRANES CELLULAIRES
  申请人：NEUROSEARCH A/S

  公开号：WO1994022807A1

  公开（公告）日：1994-10-13

  (EN) A compound having formula (I) or a pharmaceutically acceptable salt thereof, wherein X and Z each independently are NH or CH2, at least one of X and Z being NH; Y is O, S, NCN, or NH; B, D, E and F each independently are C or N, at least three of B, D, E, and F being C; and R1, R2, R3, R4, R11, R12 have the meanings set forth in the specification, pharmaceutical compositions comprising the same, and a method of treating therewith. The compounds are useful as potassium channel openers.(FR) Composé répondant à la formule (I), dans laquelle X et Z sont chacun indépendamment NH ou CH2, au moins X ou Z étant NH; Y est O, S, NCN, ou NH; B, D, E et F sont chacun indépendamment C ou N, au moins trois des groupes B, D, E et F étant C; et R1, R2, R3, R4, R11 et R12 ont les notations précisées dans la description; ou son sel pharmaceutiquement acceptable; compositions pharmaceutiques le comportant; et procédé de traitement le mettant en ÷uvre. Les composés de ce type sont utilisables comme agents de dilatation des canaux à potassium.