2,4,6-trichloro-N-(5-nitro-1,3-thiazol-2-yl)benzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4,6-trichloro-N-(5-nitro-1,3-thiazol-2-yl)benzenesulfonamide
• 化学式: C9H4Cl3N3O4S2
• 分子量: 388.6
• InChiKey: MDGBPRRRPDFBQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  142
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Treatment of myocardial infarction with 11HSD1 inhibitors
  申请人：Walker R. Brian

  公开号：US20080033046A1

  公开（公告）日：2008-02-07

  The present invention relates to a method for the treatment of myocardial infarction. In particular the invention relates to the treatment of myocardial infarction using inhibitors of a particular enzyme involved in glucocorticoid metabolism.
• [EN] INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1<br/>[FR] INHIBITEURS DE 11-BETA-HYDROXY-STEROIDE-DESHYDROGENASE DE TYPE 1
  申请人：BIOVITRUM AB

  公开号：WO2001090093A1

  公开（公告）日：2001-11-29

  The present invention relates to compounds with formula (I) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.