2-(3-chlorophenoxy)-4-[(2S)-2-(3-methylimidazol-4-yl)pyrrolidin-2-yl]benzonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-chlorophenoxy)-4-[(2S)-2-(3-methylimidazol-4-yl)pyrrolidin-2-yl]benzonitrile
• 化学式: C₂₁H₁₉ClN₄O
• 分子量: 378.9
• InChiKey: RPUIQCMGCCVCMK-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  62.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] INHIBITORS OF PRENYL-PROTEIN TRANSFERASE<br/>[FR] INHIBITEURS DE LA PRENYL-PROTEINE TRANSFERASE
  申请人：MERCK & CO INC

  公开号：WO2002078702A1

  公开（公告）日：2002-10-10

  The present invention is directed to compounds which inhibit a prenyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The compounds of the present invention comprise non-prodrug, non-thiol compounds that contain a spirocyclic pyrrolidinyl moiety. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting a prenyl-protein transferase and the prenylation of the oncogene protein Ras.