4-[[5-[[4-(3,5-Dimethylbenzoyl)piperazin-1-yl]methyl]imidazol-1-yl]methyl]benzonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[[5-[[4-(3,5-Dimethylbenzoyl)piperazin-1-yl]methyl]imidazol-1-yl]methyl]benzonitrile
• 化学式: C₂₅H₂₇N₅O
• 分子量: 413.5
• InChiKey: WKPQMEUFQFHIBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  65.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Geranylgeranyl transferase inhibitor screening assay
  申请人：——

  公开号：US20020072081A1

  公开（公告）日：2002-06-13

  The present invention is directed toward a GGTase-I competitive binding assay which can be used to determine the relative GGTase-I inhibitory potency of test compounds. The present invention is also directed toward radiolabeled geranylgeranyl-protein transferase type-I inhibitor compounds which are useful to label GGTase-I in assays, whether cell-based, tissue-based or in whole animal.

  本发明涉及一种GGTase-I竞争结合测定法，可用于确定测试化合物的相对GGTase-I抑制效力。本发明还涉及放射标记的戊二醇基蛋白转移酶-I抑制剂化合物，可用于在细胞、组织或整个动物中标记GGTase-I。
• [EN] METHOD OF PREVENTING OSTEOPOROSIS<br/>[FR] PROCEDE DE PREVENTION DE L'OSTEOPOROSE
  申请人：MERCK & CO INC

  公开号：WO2001022963A1

  公开（公告）日：2001-04-05

  The present invention relates to a method of preventing or inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of an inhibitor of geranylgeranyl-protein transferase type I.