N-[4-methoxy-3-(2-pyrrolidinyl)phenyl]-2-thiophenecarboximidamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-[4-methoxy-3-(2-pyrrolidinyl)phenyl]-2-thiophenecarboximidamide
• 英文别名: N'-(4-methoxy-3-pyrrolidin-2-ylphenyl)thiophene-2-carboximidamide
• 化学式: C₁₆H₁₉N₃OS
• 分子量: 301.412
• InChiKey: BMHKHNGOHJLIGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  87.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Novel compounds
  申请人：——

  公开号：US20020137736A1

  公开（公告）日：2002-09-26

  There are provided novel compounds of formula (I) 1 wherein R 1 , R 2 , R 3 , X and Z are as defined in the Specification and optical isomers, racemates and tautomers thereof and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme nitric oxide synthase.

  提供了一种化合物，其化学式为（I）1，其中R1、R2、R3、X和Z的定义如规范中所述，以及其光学异构体、消旋体和互变异构体，以及其药用可接受的盐；以及它们的制备过程、含有它们的组合物和它们在治疗中的用途。这些化合物是一氧化氮合酶的抑制剂。
• [EN] AMIDINE DERIVATIVES WHICH ARE INHIBITORS OF NITRIC OXIDE SYNTHASE<br/>[FR] DERIVES D'AMIDINE INHIBITEURS DE L'OXYDE NITRIQUE SYNTHASE
  申请人：ASTRAZENECA AB

  公开号：WO2001046170A1

  公开（公告）日：2001-06-28

  There are provided novel compounds of formula (I) wherein R?1, R2, R3¿, X and Z are as defined in the Specification and optical isomers, racemates and tautomers thereof and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme nitric oxide synthase.