1-[3-(2,5-Dimethylphenyl)-1,6-naphthyridin-2-yl]-3-ethylurea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-[3-(2,5-Dimethylphenyl)-1,6-naphthyridin-2-yl]-3-ethylurea
• 化学式: C₁₉H₂₀N₄O
• 分子量: 320.4
• InChiKey: QVJRZWGXMROXML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  66.9
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• TIE2 RECEPTOR KINASE INHIBITORS FOR TREATING ANGIOGENIC DISEASES
  申请人：SmithKline Beecham Corporation

  公开号：EP1372648A2

  公开（公告）日：2004-01-02
• EP1372648A4
  申请人：——

  公开号：EP1372648A4

  公开（公告）日：2004-09-01
• Novel compounds and uses thereof
  申请人：——

  公开号：US20040048888A1

  公开（公告）日：2004-03-11

  The present invention relates to novel compounds and the treatment of mammalian diseases in which inappropriate, excessive or undesirable angiogenesis has occurred and/or where excessive Tie2 receptor activity has occurred.
• US7005434B2
  申请人：——

  公开号：US7005434B2

  公开（公告）日：2006-02-28
• [EN] NOVEL COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSES ET UTILISATIONS
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2002060382A2

  公开（公告）日：2002-08-08

  The present invention relates to novel compounds and the treatment of mammalian diseases in which inappropriate, excessive or undesirable angiogenesis has occurred and/or where excessive Tie2 receptor activity has occurred.