3-[3-[(2-Amino-6-chloropyrimidin-4-yl)amino]propanoylamino]benzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[3-[(2-Amino-6-chloropyrimidin-4-yl)amino]propanoylamino]benzoic acid
• 化学式: C₁₄H₁₄ClN₅O₃
• 分子量: 335.74
• InChiKey: BABRCRALUMRSHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  130
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Antitumor agent
  申请人：The Nisshin OilliO, Ltd.

  公开号：US20030153538A1

  公开（公告）日：2003-08-14

  The present invention relates to an antitumor agent, which comprises, as an effective component, a compound selected from the group consisting of maslinic acid, erythrodiol, uvaol, betulinic acid, betulin and physiologically acceptable salts thereof or derivatives thereof.

  本发明涉及一种抗肿瘤剂，其包括作为有效成分的化合物，所述化合物选自橄榄酸、赤藓醇、尤瓦醇、白桦酸、白桦醇及其生理接受的盐或衍生物的组。
• Synthesis and methods of use of pyrimidine analogues and derivatives
  申请人：——

  公开号：US20030055249A1

  公开（公告）日：2003-03-20

  A pyrimidine derivative or analogue comprises an amino-substituted six-membered heterocyclic moiety, moiety A, linked through a linker L to a moiety B, where B is a carboxylic acid, a carboxylic acid ester, or a moiety of the structure N(Y 1 )-D, where Y 1 can be one of a variety of substituents, including hydrogen or alkyl, and D is a moiety that enhances the pharmacological effects, promotes absorption, or promotes blood-brain barrier penetration of the derivative or analogue. The moiety A can have two or three nitrogen atoms in the ring; typically, the moiety A is a pyrimidine moiety, with two nitrogen atoms in the ring. The moiety B can be one of a variety of moieties, including moieties having nootropic activity or other biological or physiological activity.

  一种嘧啶衍生物或类似物包括一种氨基取代的六元杂环基团A，通过连接物L连接到一种基团B，其中B是一种羧酸、羧酸酯，或结构为N(Y1)-D的基团，其中Y1可以是多种取代基之一，包括氢或烷基，D是一种增强药理效应、促进吸收或促进血脑屏障穿透的基团。基团A的环中可以有两个或三个氮原子；通常，基团A是一种嘧啶基团，环中有两个氮原子。基团B可以是多种基团之一，包括具有智力活性或其他生物学或生理活性的基团。
• Synthesis and methods of use pyrimidine analogues and derivatives
  申请人：——

  公开号：US20040116453A1

  公开（公告）日：2004-06-17

  A pyrimidine derivative or analogue comprises an amino-substituted six-membered heterocyclic moiety, moiety A, linked through a linker L to a moiety B, where B is a carboxylic acid, a carboxylic acid ester, or a moiety of the structure N(Y 1 )-D, where Y 1 can be one of a variety of substituents, including hydrogen or alkyl, and D is a moiety that enhances the pharmacological effects, promotes absorption, or promotes blood-brain barrier penetration of the derivative or analogue. The moiety A can have two or three nitrogen atoms in the ring; typically, the moiety A is a pyrimidine moiety, with two nitrogen atoms in the ring. The moiety B can be one of a variety of moieties, including moieties having nootropic activity or other biological or physiological activity.

  一种嘧啶衍生物或类似物包括一个氨基取代的六元杂环基团A，通过连接基L与基团B相连，其中B是羧酸，羧酸酯或结构为N（Y1）-D的基团，其中Y1可以是多种取代基之一，包括氢或烷基，D是增强衍生物或类似物的药理效应，促进吸收或促进血脑屏障穿透的基团。基团A可以在环中有两个或三个氮原子；通常，基团A是嘧啶基团，环中有两个氮原子。基团B可以是多种基团之一，包括具有神经保护活性或其他生物或生理活性的基团。
• ANTITUMOR AGENTS
  申请人：The Nisshin Oillio, Ltd.

  公开号：EP1321145A1

  公开（公告）日：2003-06-25

  The present invention relates to an antitumor agent, which comprises, as an effective component, a compound selected from the group consisting of maslinic acid, erythrodiol, uvaol, betulinic acid, betulin and physiologically acceptable salts thereof or derivatives thereof.

  本发明涉及一种抗肿瘤剂，其有效成分包括选自马斯林酸、红景天二醇、莼菜醇、白桦脂酸、白桦脂素及其生理上可接受的盐或其衍生物的化合物。
• BEAUTIFYING FOODS AND DRINKS AND PERORAL BEAUTIFYING PREPARATIONS
  申请人：The Nisshin Oillio, Ltd.

  公开号：EP1340501A1

  公开（公告）日：2003-09-03

  The present invention relates to a food or beverage comprising at least one member selected from the group consisting of 5-membered ring-containing triterpenes and physiologically acceptable salts or derivatives thereof. The present invention also relates to an orally administered whitening agent comprising, as an effective component, at least one member selected from the group consisting of 5-membered ring-containing triterpenes and physiologically acceptable salts or derivatives thereof.

  本发明涉及一种食品或饮料，其中含有至少一种选自含五元环的三萜类化合物及其生理上可接受的盐或衍生物组成的组的成员。本发明还涉及一种口服美白剂，其有效成分包括至少一种选自含五元环的三萜类化合物及其生理上可接受的盐或衍生物组成的组。