Ethyl-4-bis-(hydroxypropyl)-aminobenzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Ethyl-4-bis-(hydroxypropyl)-aminobenzoate
• 英文别名: ethyl 4-[bis(1-hydroxypropyl)amino]benzoate
• 化学式: C₁₅H₂₃NO₄
• 分子量: 281.35
• InChiKey: YRPGPHPALOFGJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  70
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• SUNSCREEN COMPOSITIONS
  申请人：L'OREAL

  公开号：US20040126336A1

  公开（公告）日：2004-07-01

  The present invention relates to improved sunscreen compositions, more preferably to improved sunscreen compositions containing at least one sunscreening agent (sunscreen) and a silicone-polyamide copolymer.

  本发明涉及改进的防晒霜组合物，更具体地涉及至少含有一种防晒剂（防晒剂）和一种硅-聚酰胺共聚物的改进防晒霜组合物。
• Hair Loss Prevention by Natural Amino Acid and Peptide Complexes
  申请人：GUPTA SHYAM K

  公开号：US20090253668A1

  公开（公告）日：2009-10-08

  This invention relates to certain skin and hair care agents of formula (I), derived from natural amino acids and peptides. These agents provide multi-functional treatment of enzyme-related skin, hair and scalp problems, for example, hair aging including premature hair loss and hair graying; male pattern baldness; hair loss from dandruff; alopecia; split ends, acne, darkened skin, dark circles around eyes, stretch marks, wrinkles and fine lines, loss of collagen, loss of skin pliability and combinations thereof:

  本发明涉及公式（I）的某些皮肤和头发护理剂，这些护理剂源自天然氨基酸和肽。这些护理剂提供多功能的酶相关皮肤、头发和头皮问题的治疗，例如，头发老化，包括过早脱发和白发；男性型脱发；头皮屑引起的脱发；脱发斑秃；分叉，痤疮，皮肤变黑，眼周黑眼圈，妊娠纹，皱纹和细纹，胶原蛋白流失，皮肤柔韧性流失和它们的组合：
• Topical Delivery System for Antiaging and Skin Whitening Agents
  申请人：GUPTA SHYAM K.

  公开号：US20090074691A1

  公开（公告）日：2009-03-19

  This invention relates to certain hydroxyaryl alkanols, alkyl amines, alkyl amino acids, alkyl amino esters, and alkyl amino alkanols (“Hydroxyaryl compounds”) of formula (I). A method of topical application of said hydroxyaryl compounds is also disclosed. The treatment of certain enzyme dysfunctions that cause skin or hair condition such as darkened skin including age spots, dark circles around the eyes, and discoloration of skin from stretch marks; skin conditions related to acne including excess facial oil and facial pore size; premature hair aging including hair loss and graying; inflammation including intra-cellular and extra-cellular inflammation; skin aging including wrinkles and fine lines; loss of collagen including thinning skin and loss of skin pliability; malfunction of tyrosinase group of enzymes; and malfunction of matrix metalloprotease group of enzymes with said hydroxyaryl compounds is also disclosed:

  本发明涉及公式（I）的某些羟基芳基丙醇、烷基胺、烷基氨基酸、烷基氨基酯和烷基氨基丙醇（“羟基芳基化合物”）。还公开了一种使用上述羟基芳基化合物的局部应用方法。本发明还公开了使用上述羟基芳基化合物治疗某些酶功能障碍，这些酶功能障碍导致皮肤或头发状况的异常，例如黑化的皮肤，包括老年斑、眼周黑眼圈和妊娠纹引起的皮肤色素沉着；与痤疮相关的皮肤状况，包括过多的面部油脂和面部毛孔大小；过早的头发老化，包括脱发和白发；炎症，包括细胞内和细胞外炎症；皮肤衰老，包括皱纹和细纹；胶原蛋白流失，包括皮肤变薄和失去弹性；酪氨酸酶类酶的功能障碍；以及基质金属蛋白酶类酶的功能障碍。
• COMPOSITIONS COMPRISING STABILIZED KETO- ENOL UV ABSORBERS
  申请人：Fares Hani M.

  公开号：US20130309185A1

  公开（公告）日：2013-11-21

  The present application provides compositions having a keto-enol UV absorber, such as avobenzone, stabilized from forming iron complexes. The stabilization is provided by a chelating polymer derived from at least one monomer having lactam or carboxylic acid functionality. In one embodiment, the compositions are sunscreens that resist staining fabrics when washed in hard water. In another embodiment, the compositions also comprise one or more iron-containing adjuvants, such as colorants, dyes, and pigments. By stabilizing the UV absorber, cosmetics can be formulated that impart broad-spectrum UV-A protection to the user. Additional ingredients can be added to the formulation, like other UV absorbers (for even broader UV-A and UV-B protection), moisturizers, actives, conditioning agents, and rheology modifiers.

  本申请提供了一种含有酮-烯醇紫外线吸收剂（如氧苯酮）的组合物，通过来自至少一种具有内酰胺或羧酸功能的单体衍生的螯合聚合物稳定其不形成铁络合物。在一种实施例中，这些组合物是防晒霜，在硬水中洗涤时不会染色织物。在另一种实施例中，这些组合物还包括一种或多种含铁辅料，如着色剂、染料和颜料。通过稳定紫外线吸收剂，可以制定化妆品，为用户提供广谱的UV-A保护。还可以向配方中添加其他成分，如其他紫外线吸收剂（以获得更广泛的UV-A和UV-B保护）、保湿剂、活性剂、调理剂和流变学改性剂。
• POLYMER-BOUND UV ABSORBERS IN PERSONAL CARE COMPOSITIONS
  申请人：ISP INVESTMENTS INC.

  公开号：US20150265522A1

  公开（公告）日：2015-09-24

  Personal care compositions comprising a polymer-bound UV absorber are described that provide enhanced properties, including customizable UV spectrum protection, broad-spectrum UV spectrum protection, water resistance, and labile UV stabilization. The polymer comprises anhydride functionality, such as maleic anhydride or a derivative thereof, and the UV absorber contains at least one hydroxyl, primary amine, or secondary amine group. The personal care compositions may be used to treat and/or protect against burns, cancers, erythema, lentigo (“liver spots”), keratotic lesions, wrinkles, and cellular changes of the skin; and/or color changes, embrittlement, lack of luster, tangles, split ends, and/or unmanageability of the hair.

  本文描述了含有聚合物结合的紫外线吸收剂的个人护理组合物，提供了增强的性能，包括可定制的紫外线光谱保护，广谱紫外线光谱保护，耐水性和不稳定的紫外线稳定性。聚合物包含酐官能团，例如马来酸酐或其衍生物，而紫外线吸收剂含有至少一个羟基，一级胺或二级胺基团。这些个人护理组合物可用于治疗和/或预防烧伤、癌症、红斑、黑色素瘤（“肝斑”）、角化病变、皱纹和皮肤细胞变化；以及头发的颜色变化、变脆、缺乏光泽、打结、分叉和/或难以管理。