Methyl 2-[[2-(hydroxymethyl)-5-oxocyclopentyl]methylsulfanyl]pyridine-3-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Methyl 2-[[2-(hydroxymethyl)-5-oxocyclopentyl]methylsulfanyl]pyridine-3-carboxylate
• 化学式: C₁₄H₁₇NO₄S
• 分子量: 295.36
• InChiKey: JVJRSDPCYUYKIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• 2,3-DISUBSTITUTED CYCLOPENTANONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL USE THEREOF
  申请人：NIPPON KAYAKU CO., LTD.

  公开号：EP0976709A1

  公开（公告）日：2000-02-02

  The present invention relates to a compound represented by the following general formula (1) (wherein X represents O, S, SO, SO2, or NH, Y is a substituted or unsubstituted hydrocarbon residue containing 1 through 6 carbon atoms and having an overall molecular weight of not less than 15 and not more than 400, and the hydrocarbon residue, when the residue is ring, may contain one or two hetero-atoms in the ring, and Z is a carboxyl group , a group derived therefrom or an aliphatic hydrocarbon residue having from 1 to 4 carbon atoms which may be substituted or unsabstituted ) or a pharmacologically acceptable salt thereof (excluding (1R,2S)-2- [ (2R)-(2-acetylamino-2-carboxyethyl) thiomethyl ] -3-oxo-1-cyclopentanecarboxylic acid (cystacyclin)), a method for production thereof and a medicinal use thereof. The compound of the present invention is useful as a neuron differentiation accelerator.

  本发明涉及由以下通式（1）代表的化合物 (其中 X 代表 O、S、SO、SO2 或 NH，Y 是含有 1 至 6 个碳原子且总分子量不小于 15 且不大于 400 的取代或未取代的烃残基，当该烃残基为环时，环中可含有一个或两个杂原子，Z 是羧基......)、或其药理学上可接受的盐（不包括 (1R,2S)-2-[(2R)-(2-乙酰氨基-2-羧乙基)硫甲基] -3-氧代-1-环戊烷羧酸（胱抑素））、其生产方法和药用用途。本发明的化合物可用作神经元分化促进剂。
• US6114364A
  申请人：——

  公开号：US6114364A

  公开（公告）日：2000-09-05