Dihydroxymethylzearalenone

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: Dihydroxymethylzearalenone
• 英文别名: (4S,9S,10S,12E)-9,10,18-trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),12,15,17-tetraene-2,8-dione
• 化学式: C₁₉H₂₄O₇
• 分子量: 364.4
• InChiKey: WFIUAGOQGGAREU-XZUJVHTDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Non-aromatic difluoro analogues of resorcylic acid lactones
  申请人：The University of North Carolina at Greensboro

  公开号：US10434085B2

  公开（公告）日：2019-10-08

  This disclosure is directed to non-aromatic difluoro analogues of resorcylic acid lactones, pharmaceutical compositions comprising non-aromatic difluoro analogues of resorcylic acid lactones, and methods of treatment comprising non-aromatic difluoro analogues of resorcylic acid lactones.

  本公开涉及非芳香族二氟类似物的间苯二酚内酯、包含非芳香族二氟类似物的间苯二酚内酯的药物组合物，以及包含非芳香族二氟类似物的间苯二酚内酯的治疗方法。
• NON-AROMATIC DIFLUORO ANALOGUES OF RESORCYLIC ACID LACTONES
  申请人：Pearce Cedric

  公开号：US20180153854A1

  公开（公告）日：2018-06-07

  This disclosure is directed to non-aromatic difluoro analogues of resorcylic acid lactones, pharmaceutical compositions comprising non-aromatic difluoro analogues of resorcylic acid lactones, and methods of treatment comprising non-aromatic difluoro analogues of resorcylic acid lactones.
• [EN] NON-AROMATIC DIFLUORO ANALOGUES OF RESORCYLIC ACID LACTONES<br/>[FR] ANALOGUES DIFLUORO NON-AROMATIQUES DE LACTONES D'ACIDE RÉSORCYLIQUE
  申请人：UNIV OF NORTH CAROLINA AT GREENSBORO

  公开号：WO2016196256A2

  公开（公告）日：2016-12-08

  This disclosure is directed to non-aromatic difluoro analogues of resorcylic acid lactones, pharmaceutical compositions comprising non-aromatic difluoro analogues of resorcylic acid lactones, and methods of treatment comprising non-aromatic difluoro analogues of resorcylic acid lactones.