N-(2-aminophenyl)-4-[N-(pyridin-3-yl)oxyacetylaminomethyl]benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-aminophenyl)-4-[N-(pyridin-3-yl)oxyacetylaminomethyl]benzamide
• 英文别名: N-(2-aminophenyl)-4-[[(2-pyridin-3-yloxyacetyl)amino]methyl]benzamide
• 化学式: C₂₁H₂₀N₄O₃
• 分子量: 376.415
• InChiKey: YVYVTPGLUVNCHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Cell differentiation inducer
  申请人：Schering Aktiengesellschaft

  公开号：US20040147569A1

  公开（公告）日：2004-07-29

  The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma. 1

  本发明中由公式（1）表示的新型苯甲酰胺衍生物和由公式（13）表示的新型苯胺酰衍生物具有诱导分化的效果，因此可用作恶性肿瘤、自身免疫性疾病、皮肤病和寄生虫治疗或改善剂。特别是，它们对于血液恶性肿瘤和实体癌具有高度的抗癌药物效果。
• New pharmaceutical combination
  申请人：Schuppan Detlev

  公开号：US20050054647A1

  公开（公告）日：2005-03-10

  Pharmaceutical combinations comprising at least one compound of general formula I-A or I-AA, and at lest one compound of general formula II) or Iia), or pharmaceutical combinations comprising at least one compound of general formula I-A or I-AA, and at least one compound of general formula II) or Iia), and an anti-hormone, and their use for the treatment of different diseases resulting by persistent angiogenesis are described.

  本文描述了包含至少一个I-A或I-AA通用式化合物和至少一个II）或Iia）通用式化合物的制药组合物，或包含至少一个I-A或I-AA通用式化合物和至少一个II）或Iia）通用式化合物以及抗激素的制药组合物，并用于治疗由持续血管生成引起的不同疾病。
• CELL DIFFERENTIATION INDUCER
  申请人：Suzuki Tsuneji

  公开号：US20100256201A1

  公开（公告）日：2010-10-07

  The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma.

  本发明的公式（1）所代表的新型苯甲酰胺衍生物和公式（13）所代表的新型苯酰胺衍生物具有诱导分化的效果，因此可作为治疗或改善恶性肿瘤、自身免疫性疾病、皮肤病和寄生虫病的治疗药物或改善剂。特别是，它们对血液恶性肿瘤和实体癌具有高度的抗癌作用。
• Benzamide derivatives useful as cell differentiation inducers
  申请人：Schering AG

  公开号：EP1437346A1

  公开（公告）日：2004-07-14

  The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma.

  本发明的式(1)代表的新型苯甲酰胺衍生物和式(13)代表的新型苯胺衍生物具有分化诱导作用，因此可用于治疗或改善恶性肿瘤、自身免疫性疾病、皮肤病和寄生虫病。特别是，它们作为抗癌药物，尤其是对血液系统恶性肿瘤和实体癌非常有效。
• THERAPEUTIC AGENT FOR RHEUMATISM CONTAINING BENZAMIDE DERIVATIVE AS ACTIVE INGREDIENT
  申请人：SANTEN PHARMACEUTICAL CO., LTD.

  公开号：EP1547585A1

  公开（公告）日：2005-06-29

  An object of the present invention is to provide a therapeutic agent for rheumatic diseases comprising a benzamide derivative as an active ingredient. The benzamide derivative according to the present invention is a compound represented by the following general formula [1] or a salt thereof as an active ingredient. In the formula, R1, R2 and R3, the same or different, are hydrogen, halogen, hydroxyl, lower alkyl, lower alkoxy, aryl, aryl-lower alkyl, aryloxy, amino, amino-lower alkyl, lower alkylamino or carboxyl, X is aryl or a heterocycle, Y is a direct bond or lower alkylene wherein the lower alkylene can contain oxygen atom(s) in the group, and Z is a direct bond or lower alkylene.

  本发明的目的是提供一种治疗风湿病的药物，其活性成分包括一种苯甲酰胺衍生物。根据本发明的苯甲酰胺衍生物是由以下通式[1]代表的化合物或其盐作为活性成分。式中，相同或不同的R1、R2和R3是氢、卤素、羟基、低级烷基、低级烷氧基、芳基、芳基-低级烷基、芳氧基、氨基、氨基-低级烷基、低级烷基氨基或羧基，X是芳基或杂环，Y是直接键或低级亚烷基，其中低级亚烷基的基团中可以含有氧原子，Z是直接键或低级亚烷基。