(2R,3R)-2-(2,4-difluorophenyl)-3-{3-[4-(1,2,3-thiadiazol-4-yl)phenyl]-1,2,4-thiadiazol-5-yl}-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R,3R)-2-(2,4-difluorophenyl)-3-{3-[4-(1,2,3-thiadiazol-4-yl)phenyl]-1,2,4-thiadiazol-5-yl}-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
• 英文别名: (2R,3R)-2-(2,4-difluorophenyl)-3-[3-[4-(thiadiazol-4-yl)phenyl]-1,2,4-thiadiazol-5-yl]-1-(1,2,4-triazol-1-yl)butan-2-ol
• 化学式: C₂₂H₁₇F₂N₇OS₂
• 分子量: 497.552
• InChiKey: DZFQCGVZPHRZDS-WHEQGISXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  159
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• Azole derivatives
  申请人：——

  公开号：US20010047017A1

  公开（公告）日：2001-11-29

  The present invention is directed to new 1-(1H-1,2,4-triazol-1-yl)butan-2-ol derivatives of the formula (I), 1 and pharmaceutically acceptable salts thereof wherein Q, R, X, Y and Z are the same as defined in the claims and the description. 1-(1H-1,2,4-triazol-1-yl)butan-2-ol derivatives of the present invention have antifungal activity and are useful for the treatment of fungal diseases.

  本发明涉及公式(I)的新型1-(1H-1,2,4-三唑-1-基)丁-2-醇衍生物及其药学上可接受的盐，其中Q、R、X、Y和Z的定义与权利要求书和说明书中定义的相同。本发明的1-(1H-1,2,4-三唑-1-基)丁-2-醇衍生物具有抗真菌活性，可用于治疗真菌病。
• 1-(H-1,2,4-TRIAZOL-1-YL)BUTAN-2-OL DERIVATIVES
  申请人：Basilea Pharmaceutica AG

  公开号：EP1286988A2

  公开（公告）日：2003-03-05
• US6319933B1
  申请人：——

  公开号：US6319933B1

  公开（公告）日：2001-11-20
• [EN] 1-(H-1,2,4-TRIAZOL-1-YL)BUTAN-2-OL DERIVATIVES<br/>[FR] DERIVES 1-(H-1,2,4-TRIAZOL-1-YL) BUTAN-2-OL
  申请人：BASILEA PHARMACEUTICA AG

  公开号：WO2001079196A2

  公开（公告）日：2001-10-25

  The present invention is directed to new 1-(1H-1,2,4-triazol-1-yl)butan-2-ol derivatives of the formula (I), and pharmaceutically acceptable salts thereof wherein Q, R, X, Y and Z are the same as defined in the claims and the description. 1-(1H-1,2,4-triazol-1-yl)butan-2-ol derivatives of the present invention have antifungal activity and are useful for the treatment of fungal diseases.