2-ethyl-4-oxo-N-phenyl-7-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]thieno[2,3-b]pyridine-5-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-ethyl-4-oxo-N-phenyl-7-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]thieno[2,3-b]pyridine-5-carboxamide
• 化学式: C₃₀H₂₄N₆O₂S
• 分子量: 532.6
• InChiKey: LGOIROQHOUWKDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  39
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  132
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Fused thiophene derivatives, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0443568A1

  公开（公告）日：1991-08-28

  Novel fused thiophene derivatives of the formula (I): wherein W is or R¹ and R² which may be same or different, are each independently hydrogen, halogen, cyano, nitro, acylamino, or a hydrocarbon residue which may be substituted; R³ is hydrogen, optionally substituted alkyl or alkenyl, or -COD wherein D is hydrogen, alkoxy, hydroxy, halogen, or optionally substituted amino; R⁴ is hydrogen, halogen or nitro; R⁶ is a residue capable of forming an anion or a residue convertible into an anion; R⁶ is hydrogen or optionally substituted alkyl or alkenyl; R⁷ is a hydrocarbon residue which may be substituted; A is a direct bond or a spacer having atomic length of two or less between the phenylene group and the phenyl group; and n is an integer of 1 or 2; and the pharmaceutically acceptable salts thereof have potent angiotensin II antagonist activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases, strokes, etc.

  式 (I) 的新型熔融噻吩衍生物： 其中 W 是 或 R¹ 和 R² 可以相同或不同，各自独立地为氢、卤素、氰基、硝基、酰氨基或可被取代的烃残基； R³ 为氢、任选取代的烷基或烯基，或 -COD 其中 D 为氢、烷氧基、羟基、卤素或任选取代的氨基；R⁴ 是氢、卤素或硝基； R⁶ 是可形成阴离子的残基或可转化为阴离子的残基； R⁶ 是氢或任选取代的烷基或烯基；R⁷是可被取代的烃残基；A是直接键或亚苯基和苯基之间原子长度为 2 或更短的间隔键；n 是 1 或 2 的整数；其药学上可接受的盐具有强效血管紧张素 II 拮抗剂活性和抗高血压活性，因此可作为治疗剂用于治疗循环系统疾病，如高血压疾病、心脏病、中风等。
• US5284661A
  申请人：——

  公开号：US5284661A

  公开（公告）日：1994-02-08