4-[8-tert-Butyl-2,4-dioxo-3-(4-trifluoromethoxy-phenyl)-1,3-diaza-spiro[4.5]dec-1-ylmethyl]-N-(1H-tetrazol-5-yl)-benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 4-[8-tert-Butyl-2,4-dioxo-3-(4-trifluoromethoxy-phenyl)-1,3-diaza-spiro[4.5]dec-1-ylmethyl]-N-(1H-tetrazol-5-yl)-benzamide
• 英文别名: 4-[[8-tert-butyl-2,4-dioxo-3-[4-(trifluoromethoxy)phenyl]-1,3-diazaspiro[4.5]decan-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamide
• 化学式: C₂₈H₃₀F₃N₇O₄
• 分子量: 585.6
• InChiKey: HDKQBFLVAVRWLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  42
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  133
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• Spirocyclic ureas, compositions containing such compounds and methods of use
  申请人：Parmee R. Emma

  公开号：US20060116366A1

  公开（公告）日：2006-06-01

  The present invention relates to spirocyclic ureas, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.

  本发明涉及螺环脲类化合物、含有此类化合物的组合物以及治疗方法。这些化合物是葡萄糖高原素受体拮抗剂，因此可用于治疗、预防或延迟2型糖尿病的发生。
• [EN] SPIROCYCLIC UREAS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE<br/>[FR] UREES SPIROCYCLIQUES, COMPOSITIONS LES CONTENANT ET PROCEDES D'UTILISATION
  申请人：MERCK & CO INC

  公开号：WO2004050039A2

  公开（公告）日：2004-06-17

  The present invention relates to spirocyclic ureas, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.