异喹啉-4-基(三甲基)锡烷 | 83629-92-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 中文名称: 异喹啉-4-基(三甲基)锡烷
• 英文名称: 4-(trimethylstannyl)-isoquinoline
• 英文别名: 4-(trimethylstannyl)isoquinoline；4-trimethylstannyl isoquinoline；4-trimethylstannylisoquinoline；isoquinolin-4-yl(trimethyl)stannane
• CAS: 83629-92-9
• 化学式: C₁₂H₁₅NSn
• 分子量: 291.968
• InChiKey: YCASVYHZRGQRBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.78
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  异喹啉-4-基(三甲基)锡烷 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 12.0h， 生成 4-[3-(1H-benzoimidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-isoquinoline
  参考文献：
  名称：

  Synthesis of 3-(1H-benzimidazol-2-yl)-5-isoquinolin-4-ylpyrazolo[1,2-b]pyridine, a potent cyclin dependent kinase 1 (CDK1) inhibitor

  摘要：

  The novel compound 3-(1H-benzimidazol-2-yl)-5-isoquinolin-4-ylpyrazolo[1,2-b]pyridine was discovered to be a potent CDK1 inhibitor. Described here is the chemistry for its synthesis, including Pd(II) catalyzed Stille coupling reaction and sulfur(0) induced benzimidazole formation. Its effects on VEGFR-2 kinase activity and tumour cell proliferation are also described.

  DOI：

  10.1016/j.bmcl.2006.12.031
• 作为产物：
  描述：

  4-溴异喹啉 、 三甲基氯硅烷 以78%的产率得到
  参考文献：
  名称：

  YAMAMOTO, YUTAKA;YANAGI, AKIHIKO, CHEM. AND PHARM. BULL., 1982, 30, N 5, 1731-1737

  摘要：

  DOI：

文献信息

• Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
  申请人：——

  公开号：US20020006943A1

  公开（公告）日：2002-01-17

  Compounds of the formula: 1 where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picomaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picomaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.

  公式为：1的化合物，在公开披露中定义的公式变量的情况下，有利地抑制或阻断了皮科玛病毒3C蛋白酶的生物活性。这些化合物以及含有这些化合物的药物组合物，可用于治疗感染一种或多种皮科玛病毒（如RVP）的患者或宿主。还描述了制备这些化合物的中间体和合成方法。
• Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents
  作者：Ronghui Lin、Peter J. Connolly、Yanhua Lu、George Chiu、Shengjian Li、Yang Yu、Shenlin Huang、Xun Li、Stuart L. Emanuel、Steven A. Middleton、Robert H. Gruninger、Mary Adams、Angel R. Fuentes-Pesquera、Lee M. Greenberger

  DOI：10.1016/j.bmcl.2007.05.029

  日期：2007.8

  5-disubstituted pyrazolo[3,4-b]pyridine cyclin-dependent kinase (CDK) inhibitors was synthesized. These compounds showed potent and selective CDK inhibitory activities and inhibited in vitro cellular proliferation in cultured human tumor cells. Selected compounds were evaluated in an in vivo tumor xenograft model. The synthesis and biological evaluation of these pyrazolo[3,4-b]pyridines and related compounds

  合成了一系列的3,5-二取代的吡唑并[3,4-b]吡啶细胞周期蛋白依赖性激酶（CDK）抑制剂。这些化合物在培养的人肿瘤细胞中表现出有效的和选择性的CDK抑制活性，并抑制体外细胞增殖。在体内肿瘤异种移植模型中评估选择的化合物。报道了这些吡唑并[3，4-b]吡啶和相关化合物的合成和生物学评价。
• Antipicornaviral compounds and compositions, their uses, and materials for their synthesis
  申请人：——

  公开号：US20030225042A1

  公开（公告）日：2003-12-04

  Compounds of the formula: 1 where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.

  公式为1的化合物，在公开说明中定义的公式变量的优点下，能够有效地抑制或阻止小肠病毒3C蛋白酶的生物活性。这些化合物以及包含这些化合物的药物组合物，对于治疗感染一种或多种小肠病毒（例如RVP）的患者或宿主非常有用。还描述了制备这些化合物的中间体和合成方法。
• Yamamoto, Yutaka; Yanagi, Akihiko, Chemical and pharmaceutical bulletin, 1982, vol. 30, # 6, p. 2003 - 2010
  作者：Yamamoto, Yutaka、Yanagi, Akihiko

  DOI：——

  日期：——
• WO2006/130673
  申请人：——

  公开号：——

  公开（公告）日：——