(2RS,3RS)-3-(3-dimethylamino-1-ethyl-1-hydroxy-2-methyl-propyl)-phenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2RS,3RS)-3-(3-dimethylamino-1-ethyl-1-hydroxy-2-methyl-propyl)-phenol
• 英文别名: 3-(3-dimethylamino-1-ethyl-1-hydroxy-2-methyl-propyl)-phenol；3-[1-(Dimethylamino)-3-hydroxy-2-methylpentan-3-yl]phenol
• 化学式: C₁₄H₂₃NO₂
• 分子量: 237.342
• InChiKey: INCYIBYTUZLVLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Combination of selected opioids with muscarine antagonists for treating urinary incontinence
  申请人：Gruenenthal GmbH

  公开号：US20040242617A1

  公开（公告）日：2004-12-02

  Active compound combinations of compounds of group A, particularly opioids, and compounds of group B, particularly anti-muscarine agents and other substances suitable for treatment of an increased urge to urinate or urinary incontinence. Related pharmaceutical formulations and methods of treatment of an increased urge to urinate or urinary incontinence are also provided.

  化合物组合的活性化合物，特别是A组化合物，尤其是阿片类化合物，以及B组化合物，特别是抗肌碱药物和其他适用于治疗尿急或尿失禁的物质。还提供了相关的药物配方和治疗尿急或尿失禁的方法。
• [DE] VERFAHREN ZUR HERSTELLUNG SUBSTITUIERTER 3-ARYL-BUTYL-AMINVERBINDUNGEN<br/>[EN] METHOD FOR THE PRODUCTION OF SUBSTITUTED 3-ARYL-BUTYL AMINE COMPOUNDS<br/>[FR] PROCEDE DE PRODUCTION DES COMPOSES D'AMINE 3-ARYLE-BUTYLE SUBSTITUE
  申请人：GRUENENTHAL GMBH

  公开号：WO2004108658A1

  公开（公告）日：2004-12-16

  Die vorliegende Erfindung betrifft ein Verfahren zur Dehydratisierung substituierter 1-Amino-3-aryl-butan-3-ol­Verbindungen zur Herstellung substituierter 3-Aryl-butylamin-Verbindungen.

  这项发明涉及一种去水代替的1-氨基-3-芳基丁-3-醇化合物制备代替的3-芳基丁胺化合物的方法。
• NOVEL PROCESS FOR PREPARING HIGHLY PURE TAPENTADOL OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
  申请人：Khunt Mayur Devjibhai

  公开号：US20130096347A1

  公开（公告）日：2013-04-18

  Provided herein is a novel, commercially viable and industrially advantageous process for the preparation of 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol (Tapentadol), or a pharmaceutically acceptable salt thereof, and its intermediates, in high yield and purity. Provided also herein are novel solid state forms of tapentadol intermediates and processes for their preparation thereof. Provided further herein is a purification process for preparing highly pure tapentadol hydrochloride.

  本文提供了一种新颖的、商业上可行的和工业上有利的制备3-[(1R,2R)-3-(二甲氨基)-1-乙基-2-甲基丙基]苯酚（Tapentadol）或其药学上可接受的盐及其中间体的高产率和高纯度的过程。本文还提供了Tapentadol中间体的新固态形式及其制备方法。本文还提供了一种纯化过程，用于制备高纯度的Tapentadol盐酸盐。
• Use of 1-Phenyl-3-Dimethylamino-propane Compounds for Treating Neuropathic Pain
  申请人：Christoph Thomas

  公开号：US20080269326A1

  公开（公告）日：2008-10-30

  Use of 1-phenyl-3-dimethylaminopropane compounds for the production of medicaments for treating neuropathic pain, preferably polyneuropathic pain, also preferably diabetic neuropathic pain, more preferably diabetic peripheral neuropathic pain, and furthermore preferably for treating diabetic peripheral neuropathy.

  使用1-苯基-3-二甲氨基丙烷类化合物制备药物，用于治疗神经病性疼痛，尤其是多发性神经病性疼痛，更好地是糖尿病神经病性疼痛，进一步地，更好地是用于治疗糖尿病性周围神经病变。
• RESOLUTION METHODS FOR ISOLATING DESIRED ENANTIOMERS OF TAPENTADOL INTERMEDIATES AND USE THEREOF FOR THE PREPARATION OF TAPENTADOL
  申请人：Khunt Mayur Devjibhai

  公开号：US20130096346A1

  公开（公告）日：2013-04-18

  Provided herein is an improved and industrially advantageous optical resolution method for resolving (2R,3R)/(2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol, and use thereof for the preparation of tapentadol or a pharmaceutically acceptable salt thereof. Provided further herein is an improved and industrially advantageous optical resolution method for resolving (2R,3R)/(2S,3S)-[3-(3-methoxyphenyl)-2-methylpentyl]-dimethylamine, and use thereof for the preparation of tapentadol or a pharmaceutically acceptable salt thereof. Disclosed also herein is an improved, commercially viable and industrially advantageous process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof in high yield and purity.

  本文提供了一种改进的、在工业上具有优势的光学分辨法，用于分离(2R,3R)/(2S,3S)-1-二甲氨基-3-(3-甲氧基苯基)-2-甲基戊-3-醇，以及其在制备tapentadol或其药学可接受的盐中的应用。此外，本文还提供了一种改进的、在工业上具有优势的光学分辨法，用于分离(2R,3R)/(2S,3S)-[3-(3-甲氧基苯基)-2-甲基戊基]-二甲胺，以及其在制备tapentadol或其药学可接受的盐中的应用。本文还披露了一种改进的、商业上可行的、在工业上具有优势的高产率和纯度的tapentadol或其药学可接受的盐的制备方法。