2-(Nonylamino)benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(Nonylamino)benzamide
• 化学式: C₁₆H₂₆N₂O
• 分子量: 262.39
• InChiKey: VLEOUCJPTBRQCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  19
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP1144399A2

  公开（公告）日：2001-10-17
• [EN] BIS-ARYLSULFONYLAMINOBENZAMIDE DERIVATIVES AND THE USE THEREOF AS FACTOR Xa INHIBITORS<br/>[FR] DERIVES DE BIS-ARYLSULFONYLAMINOBENZAMIDE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DU FACTEUR Xa
  申请人：3-DIMENSIONAL PHARMACEUTICALS, INC.

  公开号：WO1996039380A1

  公开（公告）日：1996-12-12

  (EN) The present invention is directed to non-peptidic factor Xa inhibitors which are useful for the treatment of arterial and venous thrombotic occlusive disorders, inflammation, cancer, and neurodegenerative diseases. The factor Xa inhibitors provide compounds of structure (I), wherein each R1 is independently one of alkyl, substituted alkyl, cycloalkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl; each R2 and R3 is independently one of hydrogen, alkyl, aryl or arylalkyl; Y is a bond, or is one of -(CH2)p-, cycloalkyl, aryl or C2-10 heterocycle; and m, n and p are each independently 1 to 10.(FR) L'invention concerne des inhibiteurs non-peptidiques du facteur Xa utiles dans le traitement de troubles artériopatiques et veinopatiques oblitérant thrombotiques, d'inflammations, du cancer et de maladies neurodégénératives. Les inhibiteurs du facteur Xa présentent des composés de la structure (I) dans laquelle chaque R1 représente independamment alkyle, alkyle à substitution, cycloalkyle, aryle, aryle à substitution, hétéroaryle ou hétéroaryle à substitution; Chaque R2 et R3 représentent indépendamment hydrogène, alkyle, aryle ou arylalkyle; Y représente une liaison, ou -(CH2)p- cycloalkyle, aryle ou un hétérocycle C2-10; et m, n et p sont chacun indépendamment compris entre 1 et 10.
• [EN] HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP<br/>[FR] INHIBITEURS HETEROCYCLIQUES DE THIO-UREE DES VIRUS DE L'HERPES CONTENANT DU CARBOXAMIDE ET UN GROUPE PHENYLENEDIAMINE SUBSTITUE
  申请人：AMERICAN HOME PROD

  公开号：WO2000034261A2

  公开（公告）日：2000-06-15

  Compounds of formula (I) wherein R1-R5 are independently selected from hydrogen, or substituents R9-R12 are independently hydrogen, or substituents provided that at least one of R9-12 is not hydrogen; G is a monocyclic heteroaryl: X is a bond, -NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, or thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl, useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.