(S)-2,6-二甲基-5-硝基-4-(2-三氟甲基)苯基)-1,4-二氢吡啶-3-甲酸甲酯 | 98625-26-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (S)-2,6-二甲基-5-硝基-4-(2-三氟甲基)苯基)-1,4-二氢吡啶-3-甲酸甲酯
• 中文别名: (4S)-1,4-二氢-2,6-二甲基-5-硝基-4-[2-三氟甲基)苯基]-3-吡啶甲酸甲酯
• 英文名称: methyl (4S)-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
• CAS: 98625-26-4
• 化学式: C16H15F3N2O4
• 分子量: 356.3
• InChiKey: ZFLWDHHVRRZMEI-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  84.2
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• COMPOUNDS THAT INDUCE PANCREATIC BETA-CELL EXPANSION
  申请人：Wang Weidong

  公开号：US20100130476A1

  公开（公告）日：2010-05-27

  The present invention relates to compounds and compositions for inducing the expansion of pancreatic β-cells. The invention further relates to a use of these expanded pancreatic β-cells to reversibly expand pancreatic β-cells and other quiescent cells to overcome deficits associated with degenerative and/or autoimmune diseases.

  本发明涉及用于诱导胰岛素β细胞扩张的化合物和组合物。该发明进一步涉及利用这些扩张的胰岛素β细胞来可逆地扩张胰岛素β细胞和其他静止细胞，以克服与退行性和/或自身免疫疾病相关的缺陷。
• METHODS TO INHIBIT INTRACELLULAR GROWTH OF BACTERIA AND TO TREAT BACTERIA-MEDIATED DISEASES
  申请人：AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH

  公开号：US20150209308A1

  公开（公告）日：2015-07-30

  Disclosed is a method of preventing, treating or inhibiting bacterial infections. The method comprises administering at least one of the compounds disclosed herein. Also disclosed are methods of increasing acidity of bacterial phagosomes to inhibit bacterial growth, methods of increasing mitochondrial reactive oxygen species (mROS) generation to inhibit bacterial growth in a cell, pharmaceutical compositions and uses thereof.
• SUBSTITUTED DIHYDROPYRIDINES FOR SOMATIC EMBRYOGENESIS IN PLANTS
  申请人：STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK

  公开号：US20150296779A1

  公开（公告）日：2015-10-22

  Cyclopentyl 2,7,7-trimethyl-5-oxo-4-(4-pyridinyl)-1,4,5,6,7,8-hexahydro-3-quinolinecarboxylate and similar compounds are potentiators of auxin-induced somatic embryogenesis in plants. In particular, the inventors have discovered certain of these compounds induce somatic embryogenesis in Arabidopsis in the presence of 2,4-D. Also tested is BAY K 8644. Methods of inducing somatic embryogenesis comprise exposing selected plant tissues, e.g. seed embryos, to auxins, e.g. 2.4-D and the compounds.
• Composition
  申请人：THE UNIVERSITY OF NOTTINGHAM

  公开号：US20160287536A1

  公开（公告）日：2016-10-06

  The present invention relates to compositions comprising an alpha-adrenoceptor ligand for use in the treatment of benign anorectal conditions, in particular haemorrhoids. In addition to an alpha-adrenoceptor ligand, the compositions of the inventions may additionally include a calcium channel activator. Compositions with guanfacine and S(−)BayK8644 are preferred.
• COMPOSITIONS AND METHODS FOR WILLIAMS SYNDROME (WS) THERAPY
  申请人：MASSACHUSETTS INSTITUTE OF TECHNOLOGY

  公开号：US20200316132A1

  公开（公告）日：2020-10-08

  The present disclosure relates to compositions and methods for treating Williams syndrome (WS), herein identified as a neurodevelopmental oligodendrocyte hypomyelination-associated disease, and to compositions and methods for treatment of other neurodevelopmental myelination abnormality diseases or disorders.