异噁唑烷,2-(4-氯苯基)-4-苯基-3-(3,4,5-三甲氧苯基)- | 50978-10-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 异噁唑烷,2-(4-氯苯基)-4-苯基-3-(3,4,5-三甲氧苯基)-
• 中文别名: 环美卡因硫酸盐
• 英文名称: Cyclomethycaine sulfate
• 英文别名: 3-(2-methylpiperidin-1-yl)propyl 4-cyclohexyloxybenzoate;sulfuric acid
• CAS: 50978-10-4
• 化学式: C22H35NO7S
• 分子量: 457.6
• InChiKey: FEBLWCUYHGPGOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.17
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  122
• 氢给体数：
  2
• 氢受体数：
  8

安全信息

• 海关编码：
  2933399090

文献信息

• Agent dispenser with microporous releasing diffusor
  申请人：ALZA CORPORATION

  公开号：EP0040457A2

  公开（公告）日：1981-11-25

  A dispenser is disclosed for delivering an active agent to an aqueous environment. The dispenser comprises an internal compartment with a partition that divides the compartment into a first space and a second space. The first space contains the active agent and the second space contains a gel or an osmotically effective compound. An exterior wall of a microporous polymer, or a microporous polymer and a semi- permeable polymer surrounds the compartment.

  本发明公开了一种将活性剂输送到水环境中的分配器。分配器包括一个内部隔室，隔室有一个隔板，将隔室分为第一空间和第二空间。第一空间装有活性剂，第二空间装有凝胶或渗透性有效化合物。微孔聚合物或微孔聚合物和半透聚合物组成的外壁包围着隔室。
• Dosage form for delivering acid sensitive beneficial agent
  申请人：ALZA CORPORATION

  公开号：EP0257786A2

  公开（公告）日：1988-03-02

  A dosage form (20) comprises (a) a compartment (26) formed by a first wall (25) and a second wall (26). with the first wall surrounding and facing the inside of the compartment and the second wall surrounding the first wall and facing the environment of use; (b) a beneficial agent formulation (27) in the compartment (26) (c) at least one passageway (23) through the walls (22) for dispensing the beneficial agent formulation (27) from the dosage form to the environment of use over time; characterised in that the agent formulation forms with fluid that enters the compartment a fluid environment exhibiting a pH less than 5; (d) the first wall (25) permits the passage of fluid and comprises means for keeping its structural integrity in a first fluid environment exhibiting a pH less than 5 and for losing its structural integrity in a second fluid environment exhibiting a pH greater than 5; and (e) the second wall (24) permits the passage of fluid and comprises means for keeping its structural integrity in a first fluid environment exhibiting a pH less than 5 and for keeping its structural integrity in a second environment exhibiting a pH greater than 5.

  剂型（20）包括 (a) 由第一壁（25）和第二壁（26）形成的隔室（26），第一壁环绕并朝向隔室内部， 第二壁环绕第一壁并朝向使用环境； (b) 隔室（26）中的有益制剂配方（27） (c) 至少一个穿过壁(22)的通道(23)，用于将有益制剂(27)从剂型中分配到使用环 境中；其特征在于，制剂与进入隔室的流体形成 pH 值小于 5 的流体环境； (d) 第一壁（25）允许流体通过，并包括在 pH 值小于 5 的第一流体环境中保持其 结构完整性和在 pH 值大于 5 的第二流体环境中失去其结构完整性的 装置；以及 (e) 第二壁(24)允许流体通过，包括在 pH 值小于 5 的第一流体环境中保持 结构完整性的装置和在 pH 值大于 5 的第二流体环境中保持结构 完整性的装置。
• Pharmaceutical vehicles for reducing transdermal flux
  申请人：CHEMEX PHARMACEUTICALS, Inc.

  公开号：EP0506207A2

  公开（公告）日：1992-09-30

  This invention relates to the use of a water-soluble zinc-containing compound in a topical pharmaceutical composition containing a pharmacologically active agent to enhance the skin or mucous membrane penetration and retention of the pharmacologically active agent, and to reduce the transdermal flux through the skin and mucous membrane.

  本发明涉及在含有药理活性剂的外用药物组合物中使用水溶性含锌化合物，以增强皮肤或粘膜对药理活性剂的渗透和保留，并减少通过皮肤和粘膜的透皮通量。
• Topical analgesic
  申请人：Concept Matrix Solutions

  公开号：US11116780B2

  公开（公告）日：2021-09-14

  Provided herein is a topical analgesic composition that includes an external analgesic agent, one or more pharmaceutically acceptable excipients, and at least one of a cannabinoid, terpene, and flavonoid. Also provided is a method that includes topically administering to a skin surface of a subject (e.g., human) the topical analgesic composition.

  本文提供了一种局部镇痛组合物，它包括一种外用镇痛剂、一种或多种药学上可接受的赋形剂以及大麻素、萜烯和类黄酮中的至少一种。还提供了一种方法，包括向受试者（例如人类）的皮肤表面局部施用该局部镇痛组合物。
• Anti-infective compositions, methods and systems for treating disordered tissue
  申请人：——

  公开号：US20020188028A1

  公开（公告）日：2002-12-12

  The present invention relates to the treatment of disordered epithelial tissues such as cold sores and other complications resulting from disorders such as herpes, and the like. The invention relates to the use of an anti-infective and/or antimicrobial active agent in a carrier, with vigorous agitation of the disordered epithelial tissue for topical treatment thereof under such conditions sufficient to achieve clinically discernable improvement of the disordered epithelial tissue. The preferred anti-infective and/or antimicrobial active agent comprises an organohalide, such as a quaternary ammonium compound, preferably benzalkonium chloride. The inventive method may be used also in connection with a preferred applicator configuration.

  本发明涉及治疗紊乱的上皮组织，如唇疱疹和疱疹等疾病引起的其他并发症。本发明涉及在载体中使用抗感染和/或抗菌活性剂，在足以使紊乱的上皮组织得到临床上可辨认的改善的条件下，对紊乱的上皮组织进行剧烈搅拌，以进行局部治疗。优选的抗感染和/或抗菌活性剂包括有机卤化物，如季铵盐化合物，最好是苯扎氯铵。本发明的方法也可用于优选的涂抹器配置。