3-Chloro-N-(3-chloro-4-methoxy-1H-indol-7-yl)-benzenesulfonamide | 165668-33-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Chloro-N-(3-chloro-4-methoxy-1H-indol-7-yl)-benzenesulfonamide
• 英文别名: 3-chloro-N-(3-chloro-4-methoxy-1H-indol-7-yl)benzenesulfonamide
• CAS: 165668-33-7
• 化学式: C₁₅H₁₂Cl₂N₂O₃S
• 分子量: 371.244
• InChiKey: KQUKLIUYIPNQNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  79.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• BICYCLIC HETEROCYCLIC SULFONAMIDE AND SULFONIC ESTER DERIVATIVES
  申请人：Eisai Co., Ltd.

  公开号：EP0673937A1

  公开（公告）日：1995-09-27

  Novel bicyclic heterocyclic sulfonamide and sulfonic ester derivatives represented by general formula (I) having an antitumor activity and a reduced toxicity, pharmacologically acceptable salts thereof, and a process for producing the same; wherein ring A represents an optionally substituted mono- or bicyclic aromatic group; ring B represents an optionally substituted 6-membered unsaturated hydrocarbon ring or 6-membered unsaturated heterocyclic group containing one nitrogen atom; ring C represents an optionally substituted 5-membered heterocyclic group containing one or two nitrogen atoms; W represents a single bond or -CH=CH-; X represents -NR¹- or oxygen; Y represents carbon or nitrogen; Z represents -NR²- or nitrogen; and R¹ and R² represent each independently hydrogen or lower alkyl.

  由通式(I)代表的具有抗肿瘤活性且毒性降低的新型双环杂环磺酰胺和磺酸酯衍生物、其药理学上可接受的盐，以及生产该衍生物的工艺；其中环A代表任选取代的单环或双环芳香基团，环B代表任选取代的6元不饱和烃环或含有一个氮原子的6元不饱和杂环基团；环C代表任选取代的5元杂环基团；环 B 代表任选取代的含一个氮原子的 6 元不饱和烃环或 6 元不饱和杂环基团； 环 C 代表任选取代的含一个或两个氮原子的 5 元杂环基团； W 代表单键或-CH=CH-； X 代表-NR¹-或氧； Y 代表碳或氮； Z 代表-NR²-或氮；以及 R¹ 和 R² 各自独立地代表氢或低级烷基。
• APPETITE-STIMULATING AGENTS AND REMEDIES FOR ANOREXIA
  申请人：Eisai Co., Ltd

  公开号：EP1433479A1

  公开（公告）日：2004-06-30

  An appetite-stimulating agent and a therapeutic agent for anorexia, each comprising, as an active ingredient, a sulfonamide derivative or sulfonic acid ester derivative represented by the following general formula (I): wherein the ring A represents a monocyclic or bicyclic aromatic ring which may be substituted, the ring B represents a 6-membered unsaturated hydrocarbon ring or a 6-membered unsaturated heterocyclic ring containing one nitrogen atom as a heteroatom, each of which may be substituted, the ring C represents a 5-membered heterocyclic ring containing one or two nitrogen atoms, which may be substituted, W represents a single bond or -CH=CH-, X represents -N(R1)- or an oxygen atom, Y represents a carbon atom or a nitrogen atom, Z represents -N(R2)- or a nitrogen atom, and R1 and R2 may be identical or different and each represents a hydrogen atom or a lower alkyl group, or a pharmacologically acceptable salt thereof, or a hydrate thereof.

  一种食欲刺激剂和一种厌食症治疗剂，作为活性成分，均包括由下式通式(I)代表的磺酰胺衍生物或磺酸酯衍生物： 其中环 A 代表可被取代的单环或双环芳香环、 环 B 代表 6 元不饱和烃环或含有一个氮原子作为杂原子的 6 元不饱和杂环，每个环均可被取代、 环 C 代表含有一个或两个氮原子的 5 元杂环，可被取代、 W 代表单键或-CH=CH-、 X 代表-N(R1)-或氧原子、 Y 代表碳原子或氮原子、 Z 代表-N（R2）- 或氮原子，以及 R1 和 R2 可以相同或不同，各自代表氢原子或低级烷基，或其药理上可接受的盐，或其药理上可接受的烷基。 或其药理学上可接受的盐，或其水合物。
• LYMPHOCYTIC ACTIVATION INHIBITOR AND REMEDIAL AGENT FOR AUTOIMMUNE DISEASE
  申请人：Eisai Co. Ltd

  公开号：EP1430894A1

  公开（公告）日：2004-06-23

  A lymphocyte activation inhibitor and a therapeutic agent for an autoimmune disease, each comprising, as an active ingredient, a sulfonamide derivative or sulfonic acid ester derivative represented by the following general formula (I): wherein the ring A represents a monocyclic or bicyclic aromatic ring which may be substituted, the ring B represents a 6-membered unsaturated hydrocarbon ring or a 6-membered unsaturated heterocyclic ring containing one nitrogen atom as a heteroatom, each of which may be substituted, the ring C represents a 5-membered heterocyclic ring containing one or two nitrogen atoms, which may be substituted, W represents a single bond or -CH=CH-, X represents -N(R1)- or an oxygen atom, Y represents a carbon atom or a nitrogen atom, Z represents -N(R2)- or a nitrogen atom, and R1 and R2 may be identical or different and each represents a hydrogen atom or a lower alkyl group, or a pharmacologically acceptable salt thereof, or a hydrate thereof.

  一种淋巴细胞活化抑制剂和一种自身免疫性疾病的治疗剂，作为活性成分，均包含由下式通式(I)代表的磺酰胺衍生物或磺酸酯衍生物： 其中，环 A 代表可被取代的单环或双环芳香环、 环 B 代表 6 元不饱和烃环或含有一个氮原子作为杂原子的 6 元不饱和杂环，每个环均可被取代、 环 C 代表含有一个或两个氮原子的 5 元杂环，可被取代、 W 代表单键或-CH=CH-、 X 代表-N(R1)-或氧原子、 Y 代表碳原子或氮原子、 Z 代表-N（R2）- 或氮原子，以及 R1 和 R2 可以相同或不同，各自代表氢原子或低级烷基，或其药理学上可接受的盐，或其水合物。
• Lymphocytic activation inhibitor and remedial agent for autoimmune disease
  申请人：——

  公开号：US20040235866A1

  公开（公告）日：2004-11-25

  A lymphocyte activation inhibitor and a therapeutic agent for an autoimmune disease, each comprising, as an active ingredient, a sulfonamide derivative or sulfonic acid ester derivative represented by the following general formula (I): 1 wherein the ring A represents a monocyclic or bicyclic aromatic ring which may be substituted, the ring B represents a 6-membered unsaturated hydrocarbon ring or a 6-membered unsaturated heterocyclic ring containing one nitrogen atom as a heteroatom, each of which may be substituted, the ring C represents a 5-membered heterocyclic ring containing one or two nitrogen atoms, which may be substituted, W represents a single bond or —CH═CH—, X represents —N(R 1 )— or an oxygen atom, Y represents a carbon atom or a nitrogen atom, Z represents —N(R 2 )— or a nitrogen atom, and R 1 and R 2 may be identical or different and each represents a hydrogen atom or a lower alkyl group, or a pharmacologically acceptable salt thereof, or a hydrate thereof.

  一种淋巴细胞活化抑制剂和一种自身免疫性疾病的治疗剂，作为活性成分，均包含由下式通式(I)代表的磺酰胺衍生物或磺酸酯衍生物： 1 其中环 A 代表可被取代的单环或双环芳香环、 环 B 代表 6 元不饱和烃环或含有一个氮原子作为杂原子的 6 元不饱和杂环， 每个环均可被取代、 环 C 代表含有一个或两个氮原子的 5 元杂环，可被取代、 W 代表单键或-CH═CH-、 X 代表-N(R 1 )-或一个氧原子、 Y 代表碳原子或氮原子、 Z 代表-N(R 2 )-或氮原子，以及 R 1 和 R 2 可以相同或不同，且各自代表氢原子或低级烷基，或其药理学上可接受的盐，或其水合物。
• Appetite-stimulating agents and remedies for anorexia
  申请人：——

  公开号：US20040242628A1

  公开（公告）日：2004-12-02

  An appetite-stimulating agent and a therapeutic agent for anorexia, each comprising, as an active ingredient, a sulfonamide derivative or sulfonic acid ester derivative represented by the following general formula (I): 1 wherein the ring A represents a monocyclic or bicyclic aromatic ring which may be substituted, the ring B represents a 6-membered unsaturated hydrocarbon ring or a 6-membered unsaturated heterocyclic ring containing one nitrogen atom as a heteroatom, each of which may be substituted, the ring C represents a 5-membered heterocyclic ring containing one or two nitrogen atoms, which may be substituted, W represents a single bond or —CH═CH—, X represents —N(R′)— or an oxygen atom, Y represents a carbon atom or a nitrogen atom, Z represents —N(R 2 )- or a nitrogen atom, and R 1 and R 2 may be identical or different and each represents a hydrogen atom or a lower alkyl group, or a pharmacologically acceptable salt thereof, or a hydrate thereof.