(2S)-2-(3-benzoylphenyl)propanoic acid;(2S)-2,6-diaminohexanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S)-2-(3-benzoylphenyl)propanoic acid;(2S)-2,6-diaminohexanoic acid
• 化学式: C22H28N2O5
• 分子量: 400.5
• InChiKey: VHIORVCHBUEWEP-FIZIFZEPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.63
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  144
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• [EN] CO-CRYSTAL OF KETOPROFEN, COMPOSITIONS COMPRISING THE SAME, PROCESS OF PRODUCING THE SAME, AND USES THEREOF<br/>[FR] CO-CRISTAL DE KÉTOPROFÈNE, COMPOSITIONS LE COMPRENANT, SON PROCÉDÉ DE PRODUCTION ET SES UTILISATIONS
  申请人：DOMPE FARM SPA

  公开号：WO2020126088A1

  公开（公告）日：2020-06-25

  The present invention refers to a co-crystal of Ketoprofen Lysine named Form 1, a pharmaceutical composition comprising said co-crystal, a process for its production and to its use in the treatment of pain and inflammatory diseases.

  本发明涉及一种称为Form 1的酮酸赖氨酸共晶体，包括该共晶体的制药组合物，其制备过程以及在治疗疼痛和炎症性疾病中的使用。
• CO-CRYSTAL OF KETOPROFEN, COMPOSITIONS COMPRISING THE SAME, PROCESS OF PRODUCING THE SAME, AND USES THEREOF
  申请人：Dompé farmaceutici S.p.A.

  公开号：EP3670489A1

  公开（公告）日：2020-06-24

  The present invention refers to a co-crystal of Ketoprofen lysine, a pharmaceutical composition comprising said co-crystal, a process for its production and to its use in the treatment of pain and inflammatory diseases.

  本发明涉及一种酮洛芬赖氨酸共晶体、一种包含所述共晶体的药物组合物、其生产工艺及其在治疗疼痛和炎症疾病中的用途。
• CO-CRYSTAL OF KETOPROFEN AND ITS PREPARATION, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND USES THEREOF
  申请人：Dompé farmaceutici S.p.A.

  公开号：EP3842408A1

  公开（公告）日：2021-06-30

  The present invention refers to a co-crystal of Ketoprofen Lysine named Form 4, a pharmaceutical composition comprising said co-crystal, a process for its preparation and to its use in the treatment of pain and inflammatory diseases.

  本发明涉及一种名为 Form 4 的酮洛芬赖氨酸共晶体、一种包含上述共晶体的药物组合物、其制备方法及其在治疗疼痛和炎症疾病中的用途。
• [EN] NOVEL (+)-(S)-2-(3-BENZOYLPHENYL)PROPIONIC ACID DERIVATIVES WITH ANALGESIC ACTION AND THE PROCESS FOR THE PREPARATION THEREOF<br/>[FR] NOUVEAUX DERIVES D'ACIDE (+)-(S)-2-(3-BENZOYLPHENYL)PROPIONIQUE A ACTION ANALGESIQUE ET PROCEDES DE PREPARATION
  申请人：LABORATORIOS MENARINI S.A.

  公开号：WO1996016016A1

  公开（公告）日：1996-05-30

  (EN) The present invention relates to novel (+)-(S)-2-(3-benzoylphenyl)propionic acid salts of formula (I), wherein B+ is choline or the protonated form of lysine, arginine, ornithine, D-glucamine, N-methyl-D-glucamine or imidazole. The process for the preparation comprises reacting a compound of formula (II) with lysine, arginine, ornithine, choline hydroxide, D-glucamine, N-methyl-D-glucamine or imidazole; or reacting a salt of the compound of formula (II) with the suitable organic salt. Said compounds have a high analgesic and antiinflammatory activity.(FR) On décrit de nouveaux sels d'acide (+)-(S)-2-(3-benzoylphényl) propionique de formule (I), où B+ représente choline ou la forme protonée de lysine, arginine, ornithine, D-glucamine, N-méthyl-D-glucamine ou imidazole. Leur procédé de préparation consiste à faire réagir un composé de formule (II) avec lysine, arginine, ornithine, hydroxyde de choline, D-glycamine, N-méthyle-D-glucamine ou imidazole, ou bien à faire réagir un sel du composé de formule (II) avec le sel organique approprié. Ces composés présentent une activité analgésique et anti-inflammatoire élevée.
• [EN] CO-CRYSTAL OF KETOPROFEN AND ITS PREPARATION, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND USES THEREOF<br/>[FR] CO-CRISTAL DE KÉTOPROFÈNE ET SA PRÉPARATION, COMPOSITIONS PHARMACEUTIQUES LE COMPRENANT ET LEURS UTILISATIONS
  申请人：DOMPE FARM SPA

  公开号：WO2021130162A1

  公开（公告）日：2021-07-01

  The present invention refers to a co-crystal of Ketoprofen Lysine named Form 4, a pharmaceutical composition comprising said co-crystal, a process for its preparation and to its use in the treatment of pain and inflammatory diseases.