3-Hydroxypropyl 2-[2-[2,6-dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenyl]propan-2-yl]-4-phenyl-1,3-thiazole-5-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Hydroxypropyl 2-[2-[2,6-dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenyl]propan-2-yl]-4-phenyl-1,3-thiazole-5-carboxylate
• 化学式: C₂₅H₂₂Cl₂N₄O₅S
• 分子量: 561.4
• InChiKey: LEYVZXFGECLXBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  37
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  149
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Non-steroidal IL-5 inhibitors, processes and intermediates for their preparation and pharmaceutical compositions comprising said inhibitors
  申请人：——

  公开号：US20030114453A1

  公开（公告）日：2003-06-19

  The present invention relates to IL-5 inhibiting 6-azauracil derivatives useful for treating eosinophil-dependent inflammatory diseases, to processes and intermediates for their preparation as well as to pharmaceutical compositions comprising the said derivatives. It further relates to the use of such derivatives as a medicine, and to processes for marking a receptor or imaging an organ using the said derivatives.

  本发明涉及用于治疗嗜酸性粒细胞依赖性炎症性疾病的IL-5抑制6-氨基尿嘧啶衍生物，以及用于它们的制备的过程和中间体，以及包含所述衍生物的药物组合物。还涉及将这些衍生物用作药物的用途，以及使用这些衍生物标记受体或成像器官的过程。
• INTERLEUKIN-5 INHIBITING 6-AZAURACIL DERIVATIVES
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP1206471B1

  公开（公告）日：2006-03-01
• US6911444B2
  申请人：——

  公开号：US6911444B2

  公开（公告）日：2005-06-28
• [EN] INTERLEUKIN-5 INHIBITING 6-AZAURACIL DERIVATIVES<br/>[FR] DERIVES DE 6-AZAURACILE INHIBANT L'INTERLEUKINE 5
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2001010866A1

  公开（公告）日：2001-02-15

  The present invention relates to IL-5 inhibiting 6-azauracil derivatives of formula (I) useful for treating eosinophil-dependent inflammatory diseases, to processes and intermediates for their preparation as well as to pharmaceutical compositions comprising the said derivatives. It further relates to the use of such derivatives as a medicine, and to processes for marking a receptor or imaging an organ using the said derivatives.