3,5-diamino-N-[N'-[4-[4-[2-[bis[(2S,3R)-2,3,4-trihydroxybutyl]amino]ethoxy]phenyl]butyl]carbamimidoyl]-6-chloropyrazine-2-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-diamino-N-[N'-[4-[4-[2-[bis[(2S,3R)-2,3,4-trihydroxybutyl]amino]ethoxy]phenyl]butyl]carbamimidoyl]-6-chloropyrazine-2-carboxamide
• 化学式: C₂₆H₄₁ClN₈O₈
• 分子量: 629.1
• InChiKey: DVSNKXHSHZWWAR-VNTMZGSJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  43
• 可旋转键数：
  19
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  279
• 氢给体数：
  10
• 氢受体数：
  14

文献信息

• SODIUM CHANNEL BLOCKERS
  申请人：JOHNSON Michael R.

  公开号：US20090227530A1

  公开（公告）日：2009-09-10

  The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.

  本发明涉及钠通道阻滞剂。本发明还包括使用这些创新的钠通道阻滞剂的各种治疗方法。
• METHODS OF USING SODIUM CHANNEL BLOCKERS
  申请人：JOHNSON Michael R.

  公开号：US20090062308A1

  公开（公告）日：2009-03-05

  The present invention relates to use of a compound represented by formula (I): in which at least one of R 3 and R 4 is a group represented by formula (A): where the structural variables are as defined herein. The compounds are useful for blocking sodium channels and treating a variety of conditions.

  本发明涉及使用式（I）所表示的化合物，其中R3和R4中至少有一个是由式（A）表示的基团：其中结构变量如本文所定义。这些化合物可用于阻断钠通道和治疗各种疾病。
• Sodium channel blockers
  申请人：Parion Sciences, Inc.

  公开号：US10167266B2

  公开（公告）日：2019-01-01

  The present invention relates to compounds of Formula (I) and pharmaceutical compositions thereof. Compounds of Formula (I) are epithelial sodium channel (ENaC) blockers useful in the hydration of mucosal surfaces, enhancement of mucociliary clearance, or restoration of mucosal defense in a subject. The compounds and compositions can therefore be used to treat diseases which rely on the hydration of mucosal surfaces.

  本发明涉及式（I）化合物及其药物组合物。式（I）化合物是上皮钠通道（ENaC）阻断剂，可用于粘膜表面的水合作用、提高粘膜纤毛清除率或恢复受试者的粘膜防御能力。因此，这些化合物和组合物可用于治疗依赖于粘膜表面水合作用的疾病。
• METHODS OF ENHANCING MUCOSAL HYDRATION AND MUCOSAL CLEARANCE BY TREATMENT WITH SODIUM CHANNEL BLOCKERS AND OSMOLYTES
  申请人：Johnson Ross Michael

  公开号：US20080090841A1

  公开（公告）日：2008-04-17

  The present invention relates to methods and compositions for treating diseases ameliorated by increased mucociliary clearance and mucosal hydration by administering an effective amount of a sodium channel blocker as defined herein and an osmolyte to a subject to a subject in need of increased mucociliary clearance and mucosal hydration.
• METHODS OF REDUCING RISK OF INFECTION FROM PATHOGENS
  申请人：JOHNSON Michael R.

  公开号：US20110144338A1

  公开（公告）日：2011-06-16

  Prophylactic treatment methods are provided for protection of individuals and/or populations against infection from airborne pathogens. In particular, prophylactic treatment methods are provided comprising administering a sodium channel blocker or pharmaceutically acceptable salts thereof to one or more members of a population at risk of exposure to or already exposed to one or more airborne pathogens, either from natural sources or from intentional release of pathogens into the environment.