5-[(3,5-Dimethyl-1,2-oxazol-4-yl)-hydroxymethyl]-5-methylimidazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 5-[(3,5-Dimethyl-1,2-oxazol-4-yl)-hydroxymethyl]-5-methylimidazolidine-2,4-dione
• 化学式: C₁₀H₁₃N₃O₄
• 分子量: 239.23
• InChiKey: ZPCCHPVZPTUARF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Metalloproteinase inhibitors
  申请人：——

  公开号：US20040116486A1

  公开（公告）日：2004-06-17

  Compounds of the formula (I) useful as metalloproteinase inhibitors, especially as inhibitors of MMP12, wherein R5 is a monocyclic group.

  式(I)的化合物可用作金属蛋白酶抑制剂，特别是MMP12的抑制剂，其中R5是单环基团。
• METALLOPROTEINASE INHIBITORS
  申请人：AstraZeneca AB

  公开号：EP1370535A1

  公开（公告）日：2003-12-17
• [EN] METALLOPROTEINASE INHIBITORS<br/>[FR] INHIBITEURS DE METALLOPROTEINASE
  申请人：ASTRAZENECA AB

  公开号：WO2002074750A1

  公开（公告）日：2002-09-26

  The invention provides a metalloproteinsae inhibitor compound comprising a metal binding group having formula (I), for use in the treatment of a disease or condition mediated by one or more metalloproteinase enzymes wherein X is selected from NR1, O, S; B is C or CH, Y1 and Y2 are idenpendently selected from O, S; R1 is selected from H, alkyl, haloalkyl.